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Increased Incidence and Associated Risk Factors of Aspergillosis in Patients with Bronchiectasis

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Abstract
There are insufficient data regarding the relationship between non-cystic fibrosis bronchiectasis and incident aspergillosis. We performed a population-based, matched cohort study using data from the Korean National Health Insurance database between 2003 and 2013. The incidence of aspergillosis was 50/100,000 person-years in the bronchiectasis cohort and 11/100,000 person-years in the matched cohort (subdistribution hazard ratio, 4.53; 95% confidence interval (CI), 3.25-6.32). Among the bronchiectasis cohort, chronic obstructive pulmonary disease (adjusted HR, 1.95; 95% CI, 1.07-3.57), previous pulmonary tuberculosis (adjusted HR, 3.67; 95% CI, 2.03-6.64), and non-tuberculous mycobacterial pulmonary disease (adjusted HR, 11.25; 95% CI, 1.49-85.18) increased the risk of incident aspergillosis. The incidence of aspergillosis in patients with bronchiectasis was approximately 4.5-fold that in those without bronchiectasis. Comorbid pulmonary diseases-chronic obstructive pulmonary disease, previous pulmonary tuberculosis, and non-tuberculous mycobacterial pulmonary disease-significantly increased the risk of aspergillosis in patients with bronchiectasis. Our study indicates that close monitoring is warranted for aspergillosis in patients with bronchiectasis.
Author(s)
나승원오연목Bin HwangboBumhee YangHayoung ChoiHye Yun ParkHyun LeeJang Won SohnJiin RyuKang Hyeon ChoeSeung Jun LeeSun-Young KongTaehee KimYong-Soo Kwon
Issued Date
2021
Type
Article
Keyword
AgeAspergillosisAsthmaBacterial infectionsBronchiectasisChronic obstructive pulmonary diseaseComorbidityCystic fibrosisDiabetesDiseaseepidemiologyInfectionsLung cancerLung diseasesObstructive lung diseasePopulation studiesRisk factorsTuberculosis
DOI
10.3390/jpm11050422
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7112
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_82addf06485e4aa6a8a5cd94db48de5d&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Increased%20Incidence%20and%20Associated%20Risk%20Factors%20of%20Aspergillosis%20in%20Patients%20with%20Bronchiectasis&offset=0&pcAvailability=true
Publisher
JOURNAL OF PERSONALIZED MEDICINE
Location
스위스
Language
영어
ISSN
2075-4426
Citation Volume
11
Citation Number
5
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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