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Increased mortality in patients with non cystic fibrosis bronchiectasis with respiratory comorbidities

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Abstract
There are limited data regarding whether mortality is higher in patients with non cystic fibrosis bronchiectasis (bronchiectasis) than in those without bronchiectasis. Using 2005-2015 data from the Korean National Health Insurance Service, we evaluated hazard ratio (HR) for all-cause mortality in the bronchiectasis cohort relative to the matched cohort. The effect of comorbidities over the study period on the relative mortality was also assessed. All-cause mortality was significantly higher in the bronchiectasis cohort than in the matched cohort (2505/100,000 vs 2142/100,000 person-years, respectively; P<0.001). Mortality risk was 1.15-fold greater in the bronchiectasis cohort than in the matched cohort (95% confidence interval [CI] 1.09-1.22); mortality was greatest among elderly patients (HR=1.17, 95% CI 1.10-1.25) and men (HR=1.19, 95% CI 1.10-1.29). Comorbidities over the study period significantly increased the risk of death in the bronchiectasis cohort relative to the matched cohort: asthma (adjusted HR=1.20, 95% CI 1.11-1.30), chronic obstructive pulmonary disease (adjusted HR=1.24, 95% CI 1.15-1.34), pneumonia (adjusted HR=1.50, 95% CI 1.39-1.63), lung cancer (adjusted HR=1.85, 95% CI 1.61-2.12), and cardiovascular disease (adjusted HR=1.34, 95% CI 1.23-1.45). In contrast, there were no significant differences in the risk of death in patients without bronchiectasis-related comorbidities and the matched cohort, except in the case of non-tuberculous mycobacterial infection. In conclusion, all-cause mortality was higher in patients with bronchiectasis cohort than those without bronchiectasis, especially in elderly patients and men. Comorbidities over the study period played a major role in increasing mortality in patients with bronchiectasis relative to those without bronchiectasis.
Author(s)
나승원오연목Bumhee YangDong Won ParkHayoung ChoiHo Joo YoonHye Yun ParkHyun LeeJang Won SohnJi-Yong MoonSang-Heon KimSooim SinSung Jun ChungTae-Hyung KimTai Sun ParkYong Suk JoYoomi YeoYoulim KimYun Jin Kim
Issued Date
2021
Type
Article
Keyword
AsthmaBronchiectasisCardiovascular diseasesChronic obstructive pulmonary diseaseCystic fibrosisEpidemiologyLung cancerLung diseasesMortalityObstructive lung diseasePrognosisRisk factorsTuberculosis
DOI
10.1038/s41598-021-86407-8
URI
http://oak.ulsan.ac.kr/handle/2021.oak/7114
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/search?query=any,contains,Increased%20mortality%20in%20patients%20with%20non%20cystic%20fibrosis%20bronchiectasis%20with%20respiratory%20comorbidities&amp;tab=default_tab&amp;search_scope=default_scope&amp;vid=ULSAN&amp;lang=ko_KR&amp;offset=0&amp;pcAvailability=true&amp;fromRedirectFilter=true
Publisher
SCIENTIFIC REPORTS
Location
영국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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