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Redevelopment after spontaneous sputum conversion in noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease

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Abstract
Background: Although spontaneous sputum conversion can occur in noncavitary nodular bronchiectatic (NC-NB) Mycobacterium avium complex lung disease (MAC-LD), little is known about redevelopment after spontaneous conversion. We investigated the redevelopment phenomenon after spontaneous sputum conversion in patients with NC-NB MAC-LD.

Material and methods: Among patients diagnosed with NC-NB MAC-LD between 2000 and 2013, 140 patients who experienced spontaneous sputum conversion, and whose follow-up duration after conversion was >6 months, were enrolled at a tertiary referral center in South Korea. Their medical records were retrospectively reviewed.

Results: Of the 140 patients, 34 (24.3%) underwent redevelopment during the median follow-up period of 71.0 months (interquartile range [IQR], 58.8-87.5). Redevelopment occurred at a median interval of 25.0 months (IQR, 11.5-41.8) after spontaneous sputum conversion. The mean age of the 34 patients with redevelopment was 63.6 years, and 73.5% were women. No statistically significant differences in clinical characteristics were noted between the 34 patients with redevelopment and those with persistent conversion. Among the 34 patients with redevelopment, 6 received treatment at a median interval of 8 months (IQR, 1.5-16.8) after redevelopment. No significant differences in clinical characteristics were noted between the six treated and 28 untreated patients.

Conclusion: At least approximately 24% of patients with spontaneous sputum conversion in NC-NB MACLD had redevelopment, and a portion of them required treatment. These findings suggest that long-term follow-up is necessary for patients with NC-NB MAC-LD, even those who experience spontaneous sputum conversion

. (c) 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Author(s)
심태선조경욱Ock-Hwa KimYong Pil Chong
Issued Date
2021
Type
Article
Keyword
Mycobacterium avium complexRedevelopmentSpontaneous sputum conversion
DOI
10.1016/j.jiac.2021.03.006
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7125
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2503652213&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Redevelopment%20after%20spontaneous%20sputum%20conversion%20in%20noncavitary%20nodular%20bronchiectatic%20Mycobacterium%20avium%20complex%20lung%20disease
Publisher
JOURNAL OF INFECTION AND CHEMOTHERAPY
Location
네덜란드
Language
영어
ISSN
1341-321X
Citation Volume
27
Citation Number
8
Citation Start Page
1156
Citation End Page
1161
Appears in Collections:
Medicine > Medicine
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