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Cavity formation and its predictors in noncavitary nodular bronchiectatic Mycobacterium avium complex pulmonary disease

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Abstract
Introduction: The temporal dynamics of cavity formation in patients with the noncavitary nodular bronchiectatic (NC-NB) form of Mycobacterium avium complex pulmonary disease (MAC-PD) have not yet been well described. We aimed to investigate the development of new cavities in the NC-NB form of MAC-PD.

Methods: Of the patients diagnosed with NC-NB-type MAC-PD between 2002 and 2013 and followed-up until July 2018 at a tertiary referral center in South Korea, we identified 589 patients who underwent follow-up chest computed tomography at least once after the diagnosis and retrospectively analysed their medical records.

Results: The patients' mean age was 62.0 years, 64.7% were women. During the median follow-up of 3.8 years (interquartile range [IQR] 1.7-5.9), new cavity formation was noted in 51 (8.7%) patients. The median interval between the diagnosis of NC-NB MAC-PD and cavity formation was 3.7 years (IQR 1.8-5.4), with a constant occurrence over time. The Cox regression analysis showed that a history of pulmonary tuberculosis (adjusted hazard ratio [HR] 1.85; 95% confidence interval [CI] 1.06-3.23; P = 0.030) and M. intracellulare as the causative organism (adjusted HR 2.03; 95% CI 1.15-3.59; P = 0.014) were independently associated with new cavity formation.

Conclusions: New cavity formation was noted in 8.7% of the patients with NC-NB MAC-PD in approximately 4 years after diagnosis, particular in those infected with M. intracellulare and those with a previous history of tuberculosis.
Author(s)
심태선조경욱Dong-Woo HanOck-Hwa Kim
Issued Date
2021
Type
Article
Keyword
AnalysisAntitubercular agentsCavity formationLung diseasesMedical recordsMycobacterium avium complexNoncavitary nodular bronchiectaticTuberculosis
DOI
10.1016/j.rmed.2021.106340
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7127
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2492660216&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Cavity%20formation%20and%20its%20predictors%20in%20noncavitary%20nodular%20bronchiectatic%20Mycobacterium%20avium%20complex%20pulmonary%20disease&offset=0&pcAvailability=true
Publisher
RESPIRATORY MEDICINE
Location
영국
Language
영어
ISSN
0954-6111
Citation Volume
179
Citation Number
0
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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