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Predictive Role of Prior Radiotherapy and Immunotherapy-Related Adverse Effects in Advanced NSCLC Patients Receiving Anti-PD-1/L1 Therapy

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Abstract
The present study evaluated the impact of prior radiotherapy (RT) on patients with advanced non-small cell lung cancer (NSCLC) receiving therapy with immune checkpoint inhibitors (ICIs) and further assessed the prognostic factors in patients receiving both RT and ICI. Patients diagnosed with NSCLC at the Catholic Medical Center and Asan Medical Center between January 2016 and October 2020 and who received immunotherapy were retrospectively reviewed. Among 240 patients, poor Eastern Cooperative Oncology Group (ECOG) score, high PD-L1 expression, and ICI-related adverse events (AE) were significantly associated with progression-free survival (PFS) (HR, 2.654; 95% CI, 1.484-4.749; p = 0.001; HR, 0.645; 95% CI, 0.449-0.926, p = 0.017; HR, 0.430; 95% CI, 0.229-0.808; p = 0.009, respectively). Among patients who received both RT and immunotherapy, poor ECOG status, squamous cell carcinoma, and ICI-related AE were significant factors associated with poor PFS (HR, 2.430; 95% CI, 1.464-4.034; p = 0.001; HR, 0.667; 95% CI, 0.455-0.978, p = 0.038; HR, 0.520; 95% CI, 0.284-0.953, p = 0.034, respectively). The present study showed that prior RT showed no significant independent association with primary outcomes in patients with advanced NSCLC receiving immunotherapy. In patients who received both RT and immunotherapy, clinical parameters, including ICI-related AEs, were independently predictive of PFS.
Author(s)
최창민Chang Dong YeoHye Seon KangJeong Uk LimJin Woo KimJu Sang KimSeung Joon KimSoo Han KimSung Kyoung Kim
Issued Date
2021
Type
Article
Keyword
adverse eventsCancer therapiesChemotherapyDrug dosagesImmunotherapyLung cancerMedical prognosisMetastasisMutationPatientsRadiation therapyradiotherapy
DOI
10.3390/jcm10163719
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7134
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_9f803fd24dfb4a87b0ed6494a112b965&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Predictive%20Role%20of%20Prior%20Radiotherapy%20and%20Immunotherapy-Related%20Adverse%20Effects%20in%20Advanced%20NSCLC%20Patients%20Receiving%20Anti-PD-1%2FL1%20Therapy&offset=0&pcAvailability=true
Publisher
JOURNAL OF CLINICAL MEDICINE
Location
스위스
Language
영어
ISSN
2077-0383
Citation Volume
10
Citation Number
16
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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