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Diagnostic Performance of Electromagnetic Navigation Bronchoscopy-Guided Biopsy for Lung Nodules in the Era of Molecular Testing

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Abstract
Electromagnetic navigation bronchoscopy (ENB) is an emerging technique used to evaluate peripheral lung lesions. The aim of this study was to determine the diagnostic yield, safety profile, and adequacy of specimens obtained using ENB for molecular testing. This single-center, prospective pilot study recruited patients with peripheral pulmonary nodules that were not suitable for biopsy via percutaneous transthoracic needle biopsy methods. The possibility of molecular testing, including epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and programmed death ligand 1 (PD-L1), was identified with non-small cell lung cancer (NSCLC) tissue obtained using ENB. ENB-guided biopsy was performed on 30 pulmonary nodules in 30 patients. ENB-guided biopsy was successfully performed in 96.6% (29/30) of cases, but one case failed to approach the target lesion. The diagnostic accuracy of ENB-guided biopsy was 68.0% (17/25). Biopsy-related pneumothorax occurred in one patient and there was no major bleeding or deaths related to the procedure. Among 13 patients diagnosed with NSCLC, molecular testing was successfully performed in 92.3% (12/13). ENB-guided biopsy demonstrated acceptable accuracy and excellent sample adequacy, with a high possibility of achieving molecular testing and a good safety profile to evaluate peripheral pulmonary nodules, even when the percutaneous approach was difficult and/or dangerous.
Author(s)
김미영오상영장세진최창민황희상Ju Hyun OhSeulgi KimWonjun Ji
Issued Date
2021
Type
Article
Keyword
accuracyAnesthesiaBiomarkersBiopsyBronchoscopyCathetersCloningdiagnostic yieldelectromagnetic navigation bronchoscopyLung cancerlung noduleMedical screeningMutationNavigation systemsPneumothoraxsafetyStatistical analysisTomographyVariables
DOI
10.3390/diagnostics11081432
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7135
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_71018366a3404f5a8e322e2a8a0b0333&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Diagnostic%20Performance%20of%20Electromagnetic%20Navigation%20Bronchoscopy-Guided%20Biopsy%20for%20Lung%20Nodules%20in%20the%20Era%20of%20Molecular%20Testing&offset=0&pcAvailability=true
Publisher
DIAGNOSTICS
Location
스위스
Language
영어
ISSN
2075-4418
Citation Volume
11
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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