Sequential treatment of afatinib and osimertinib or other regimens in patients with advanced non-small-cell lung cancer harboring EGFR mutations: Results from a real-world study in South Korea
- Abstract
- Objectives The optimal sequence for the administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for treating non-small cell lung cancer (NSCLC) is still unclear. This study aimed to evaluate the efficacy of sequential afatinib and osimertinib treatment in patients with NSCLC harboring EGFR mutations. Materials and methods Electronic records of patients with EGFR-mutated NSCLC, who were administered afatinib and osimertinib (group A) or other chemotherapy (group B) between October 2014 and 2019, across 16 hospitals in South Korea were reviewed. The primary outcome, time on treatment (TOT), secondary outcome, and overall survival (OS) were estimated using the Kaplan-Meier method and log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. Results Of the 737 patients who received frontline afatinib treatment, 324 with complete records were selected (group A: 126, group B: 198). All patients in group A were T790M positive after afatinib, while patients in group B were all negative or unknown. The median TOT was 35.4 months (95% confidence interval [CI]: 27.7-45.6) in group A and 20.8 months (95% CI: 19.4-24.0) in group B. The median TOT with afatinib was 13.0 months (95% CI: 12.0-13.9) overall and 15.7 months (95% CI: 13.9-17.3) in group A. The 2- and 3-year survival rates were 86.0 and 69.3% in group A and 75.9 and 55.3% in group B, respectively. Conclusion Sequential afatinib and osimertinib treatment resulted in better survival rates than treatment with afatinib followed by other chemotherapies.
- Author(s)
- 최창민; Chan Kwon Park; Cheol-Kyu Park; Jeong Eun Lee; Jeong Seon Ryu; Kye Young Lee; Mi-Hyun Kim; Sang Hoon Lee; Sei Hoon Yang; Seong Hoon Yoon; Seung Hun Jang; Seung Joon Kim; Shin Yup Lee; Sung Yong Lee; Tae Won Jang; Taeyun Kim; Yoon Soo Chang
- Issued Date
- 2021
- Type
- Article
- Keyword
- afatinib; Cancer; Cancer therapies; Care and treatment; Chemotherapy; Data collection; EGFR; Epidermal growth factor; Epidermal growth factor receptors; Genetic aspects; Lung cancer; Lung cancer; Non-small cell; Metastasis; Mutation; Non-small cell lung carcinoma; NSCLC; Oncology; Experimental; osimertinib; Patients; Protein-tyrosine kinase; Rankings; real‐world data; Remission (Medicine); Research; Small cell lung carcinoma; Tyrosine
- DOI
- 10.1002/cam4.4127
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7136
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_fbb820ad007b4aaaa5c7f065285aa49f&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Sequential%20treatment%20of%20afatinib%20and%20osimertinib%20or%20other%20regimens%20in%20patients%20with%20advanced%20non-small-cell%20lung%20cancer%20harboring%20EGFR%20mutations:%20Results%20from%20a%20real-world%20study%20in%20South%20Korea&offset=0&pcAvailability=true
- Publisher
- CANCER MEDICINE
- Location
- 미국
- Language
- 영어
- ISSN
- 2045-7634
- Citation Volume
- 10
- Citation Number
- 17
- Citation Start Page
- 5809
- Citation End Page
- 5822
-
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