KLI

Clinical Applications of Liquid Biopsy in Non-Small Cell Lung Cancer Patients: Current Status and Recent Advances in Clinical Practice

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Abstract
Recent advances in targeted and immune therapies have enabled tailored treatment strategies for advanced lung cancer. Identifying and understanding the genomic alterations that arise in the course of tumor evolution has become hugely valuable, but tissue biopsies are often insufficient for representing the whole cancer genome due to tumor heterogeneity. A liquid biopsy refers to the isolation and analysis of any tumor-derived material in the blood, and recent studies of this material have mostly focused on cell-free tumor DNA (ctDNA) in plasma. Indeed, liquid biopsy analysis is now expected to expand in utility and scope in clinical practice. In this review, we assess the biology and technical aspects of ctDNA analysis and discuss how it is currently applied in the clinic. Key points: Liquid biopsy is a potentially powerful tool in the era of personalized medicine for guiding targeted therapies in non-small cell lung cancer.
Author(s)
이재철최창민Shinhee Park
Issued Date
2021
Type
Article
Keyword
BiopsyCancer therapiesClinical medicineDrug resistanceFDA approvalGenesGenomesliquid biopsyLung cancerMethodsMutationnon-small cell lung carcinomaPlsasmaReviewTumors
DOI
10.3390/jcm10112236
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7138
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_ca08be04bfab426eb94e1c4ac10a60f5&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinical%20Applications%20of%20Liquid%20Biopsy%20in%20Non-Small%20Cell%20Lung%20Cancer%20Patients:%20Current%20Status%20and%20Recent%20Advances%20in%20Clinical%20Practice&offset=0&pcAvailability=true
Publisher
JOURNAL OF CLINICAL MEDICINE
Location
스위스
Language
영어
ISSN
2077-0383
Citation Volume
10
Citation Number
11
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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