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The Effects of Simultaneous Pulmonary Rehabilitation during Thoracic Radiotherapy in the Treatment of Malignant Diseases

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Abstract
Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR).
Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment.
Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV1) and FEV1/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. ?10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively).
The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017).
Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV1, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR’s effects during thoracic radiotherapy.
Author(s)
김수산김원송시열이세원이승학최창민Hyang Yi LeeMyeong Geun Choi
Issued Date
2021
Type
Article
Keyword
OriginalPulmonary Function TestsPulmonary RehabilitationRadiotherapy내과학
DOI
10.4046/trd.2020.0135
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7141
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9770121&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20Effects%20of%20Simultaneous%20Pulmonary%20Rehabilitation%20during%20Thoracic%20Radiotherapy%20in%20the%20Treatment%20of%20Malignant%20Diseases&offset=0&pcAvailability=true
Publisher
Tuberculosis and Respiratory Diseases
Location
대한민국
Language
영어
ISSN
1738-3536
Citation Volume
84
Citation Number
2
Citation Start Page
148
Citation End Page
158
Appears in Collections:
Medicine > Medicine
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