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Clinicopathological Characteristics and Disease-Free Survival in Patients with Hurthle Cell Carcinoma: A Multicenter Cohort Study in South Korea

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Abstract
Background: Hurthle cell carcinoma (HCC), a type of thyroid carcinoma, is rare in South Korea, and few studies have investigated its prognosis.

Methods: This long-term multicenter retrospective cohort study evaluated the clinicopathological features and clinical outcomes in patients with HCC who underwent thyroid surgery between 1996 and 2009.

Results: The mean age of the 97 patients included in the study was 50.3 years, and 26.8% were male. The mean size of the primary tumor was 3.2 +/- 1.8 cm, and three (3.1%) patients had distant metastasis at initial diagnosis. Ultrasonographic findings were available for 73 patients; the number of nodules with low-, intermediate-, and high suspicion was 28 (38.4%), 27 (37.0%), and 18 (24.7%), respectively, based on the Korean-Thyroid Imaging Reporting and Data System. Preoperatively, follicular neoplasm (FN) or suspicion for FN accounted for 65.2% of the cases according to the Bethesda category, and 13% had malignancy or suspicious for malignancy. During a median follow-up of 8.5 years, eight (8.2%) patients had persistent/recurrent disease, and none died of HCC. Older age, gross extrathyroidal extension (ETE), and widely invasive types of tumors were significantly associated with distant metastasis (all P<0.01). Gross ETE (hazard ratio [HR], 27.7; 95% confidence interval [CI], 2.2 to 346.4; P=0.01) and widely invasive classification (HR, 6.5; 95% CI, 1.1 to 39.4; P=0.04) were independent risk factors for poor disease-free survival (DFS).

Conclusion: The long-tenn prognosis of HCC is relatively favorable in South Korea from this study, although this is not a nationwide data, and gross ETE and widely invasive cancer are significant prognostic factors for DFS. The diagnosis of HCC by ultrasonography and cytopathology remains challenging.
Author(s)
김미화김은숙김보현김희경강예은전민지김태용강호철김원배송영기김미진김원구
Issued Date
2021
Type
Article
Keyword
Thyroid cancer&nbsp;Hurthle cell carcinoma&nbsp;Ultrasonography&nbsp;Prognosis&nbsp;Recurrence
DOI
10.3803/EnM.2021.1151
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7188
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9876868&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Clinicopathological%20Characteristics%20and%20Disease-Free%20Survival%20in%20Patients%20with%20Hurthle%20Cell%20Carcinoma:%20A%20Multicenter%20Cohort%20Study%20in%20South%20Korea&amp;offset=0&amp;pcAvailability=true
Publisher
ENDOCRINOLOGY AND METABOLISM
Location
대한민국
Language
영어
ISSN
2093-596X
Citation Volume
36
Citation Number
5
Citation Start Page
1078
Citation End Page
1085
Appears in Collections:
Medicine > Medicine
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