Clinicopathological Characteristics and Disease-Free Survival in Patients with Hurthle Cell Carcinoma: A Multicenter Cohort Study in South Korea
- Abstract
- Background: Hurthle cell carcinoma (HCC), a type of thyroid carcinoma, is rare in South Korea, and few studies have investigated its prognosis.
Methods: This long-term multicenter retrospective cohort study evaluated the clinicopathological features and clinical outcomes in patients with HCC who underwent thyroid surgery between 1996 and 2009.
Results: The mean age of the 97 patients included in the study was 50.3 years, and 26.8% were male. The mean size of the primary tumor was 3.2 +/- 1.8 cm, and three (3.1%) patients had distant metastasis at initial diagnosis. Ultrasonographic findings were available for 73 patients; the number of nodules with low-, intermediate-, and high suspicion was 28 (38.4%), 27 (37.0%), and 18 (24.7%), respectively, based on the Korean-Thyroid Imaging Reporting and Data System. Preoperatively, follicular neoplasm (FN) or suspicion for FN accounted for 65.2% of the cases according to the Bethesda category, and 13% had malignancy or suspicious for malignancy. During a median follow-up of 8.5 years, eight (8.2%) patients had persistent/recurrent disease, and none died of HCC. Older age, gross extrathyroidal extension (ETE), and widely invasive types of tumors were significantly associated with distant metastasis (all P<0.01). Gross ETE (hazard ratio [HR], 27.7; 95% confidence interval [CI], 2.2 to 346.4; P=0.01) and widely invasive classification (HR, 6.5; 95% CI, 1.1 to 39.4; P=0.04) were independent risk factors for poor disease-free survival (DFS).
Conclusion: The long-tenn prognosis of HCC is relatively favorable in South Korea from this study, although this is not a nationwide data, and gross ETE and widely invasive cancer are significant prognostic factors for DFS. The diagnosis of HCC by ultrasonography and cytopathology remains challenging.
- Author(s)
- 김미화; 김은숙; 김보현; 김희경; 강예은; 전민지; 김태용; 강호철; 김원배; 송영기; 김미진; 김원구
- Issued Date
- 2021
- Type
- Article
- Keyword
- Thyroid cancer; Hurthle cell carcinoma; Ultrasonography; Prognosis; Recurrence
- DOI
- 10.3803/EnM.2021.1151
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7188
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9876868&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinicopathological%20Characteristics%20and%20Disease-Free%20Survival%20in%20Patients%20with%20Hurthle%20Cell%20Carcinoma:%20A%20Multicenter%20Cohort%20Study%20in%20South%20Korea&offset=0&pcAvailability=true
- Publisher
- ENDOCRINOLOGY AND METABOLISM
- Location
- 대한민국
- Language
- 영어
- ISSN
- 2093-596X
- Citation Volume
- 36
- Citation Number
- 5
- Citation Start Page
- 1078
- Citation End Page
- 1085
-
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