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Pancreatic/peripancreatic neurogenic tumor; little known masses not to be missed

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Abstract
Background: Retroperitoneal neurogenic tumors are extremely rare pathological entities; therefore, few clinical features and natural courses, especially originating from the pancreatic/peripancreatic regions, have been reported. This study aimed to investigate the clinicopathological features of pancreatic and peripancreatic neurogenic tumors and assess the diagnostic value of computed tomography (CT) and endoscopic ultrasound-guided fine needle biopsy (EUS-FNB).

Methods: Between 2006 and 2018, patients who were diagnosed with neurogenic tumors were included. In total, 90 histologically confirmed cases of neurogenic tumors located in the pancreatic/peripancreatic regions were selected for analysis.

Results: The mean age was 49.2 ± 13.1 years. There were no differences in sex distribution of the tumors. Schwannomas (44.4%) and paragangliomas (41.1%) were the most common neurogenic tumors. The sensitivity of CT was 62.2% in 90 cases. EUS-FNB was performed in 30 cases and the sensitivity of it was 83.3%. The diagnosis of neurogenic tumors with EUS-FNB or CT was not significantly associated with tumor location and size. Surgical resection was performed in 78 cases. Of the 12 patients who did not undergo surgery, 10 cases were followed-up without any increase in tumor size.

Conclusions: Through the present study, we verified radiological, pathological, and clinical aspects of the pancreatic/peripancreatic neurogenic tumors which little known before, therefore, this study can serve as the basis for research to present an optimal diagnosis and treatment of neurogenic tumors. In addition, EUS-FNB is useful in the diagnosis of pancreatic/peripancreatic neurogenic tumors with relatively high sensitivity and can help establish therapeutic plans before the surgery.
Author(s)
김명환박도현박현진서동완송태준오동욱이상수이성구황준성
Issued Date
2021
Type
Article
Keyword
Endoscopic ultrasound-guided fine needle biopsyGanglioneuromaNeurilemmomaParagangliomaNeurogenic tumor
DOI
10.1016/j.pan.2021.08.005
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7189
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2566045907&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Pancreatic%2Fperipancreatic%20neurogenic%20tumor;%20little%20known%20masses%20not%20to%20be%20missed&offset=0&pcAvailability=true
Publisher
PANCREATOLOGY
Location
오스트리아
Language
영어
ISSN
1424-3903
Citation Volume
21
Citation Number
7
Citation Start Page
1386
Citation End Page
1394
Appears in Collections:
Medicine > Medicine
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