KLI

Deep Inspiration-Provoked Cough: A Sign of Cough Reflex Arc Hypersensitivity

Metadata Downloads
Abstract
Deep inspiration-provoked cough (DIPC) is a form of allotussia. Allotussia is thought to be a manifestation of cough reflex arc hypersensitivity but objective evidence about this is lacking. 36 subjects with chronic cough and 25 healthy subjects underwent mannitol and citric acid cough provocation tests. DIPC was defined as two or more coughs after deep inhalation of an empty mannitol capsule. Citric acid was administered utilizing a dosimetric nebulizer during controlled tidal breathing. Nine subjects demonstrated DIPC, 8/36 subjects with chronic cough and 1/25 healthy subjects (p = 0.048). The concentration of citric acid to provoke five or more coughs (C5) was 23.4 (63.8) mM among subjects with DIPC and 750 (2941) mM among the subjects without it (p = 0.006). The number of deep inspiration-provoked coughs correlated with the citric acid C5 (Rs -0.38, p = 0.002). In conclusion, DIPC, a form of allotussia, is associated with cough reflex arc hypersensitivity. Trial Registration Number. ClinicalTrials.gov database KUH5801136.
Author(s)
송우정Hanna M. NurmiHeikki O. Koskela
Issued Date
2021
Type
Article
Keyword
Allergic reactionAllergyChronic DiseaseCitric acidCitric Acid - adverse effectsCoughCough - chemically inducedHumansMedicineMedicine & Public HealthPneumology/Respiratoroy SystemReflex
DOI
10.1007/s00408-021-00476-0
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7205
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2573442513&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Deep%20Inspiration-Provoked%20Cough:%20A%20Sign%20of%20Cough%20Reflex%20Arc%20Hypersensitivity&offset=0&pcAvailability=true
Publisher
LUNG
Location
미국
Language
영어
ISSN
0341-2040
Citation Volume
199
Citation Number
5
Citation Start Page
501
Citation End Page
505
Appears in Collections:
Medicine > Medicine
공개 및 라이선스
  • 공개 구분공개
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.