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Effect of alcohol consumption on the risk of adverse events in atrial fibrillation: from the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF) registry

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Alternative Title
Europace. 2021 Apr 6;23(4):548-556.
Abstract
Aims: The aim of this study is to determine the relationship between alcohol consumption and atrial fibrillation (AF)-related adverse events in the AF population.

Methods and results: A total of 9411 patients with nonvalvular AF in a prospective observational registry were categorized into four groups according to the amount of alcohol consumption-abstainer-rare, light (<100 g/week), moderate (100-200 g/week), and heavy (≥200 g/week). Data on adverse events (ischaemic stroke, transient ischaemic attack, systemic embolic event, or AF hospitalization including for AF rate or rhythm control and heart failure management) were collected for 17.4 ± 7.3 months. A Cox proportional hazard models was performed to calculate hazard ratios (HRs), and propensity score matching was conducted to validate the results. The heavy alcohol consumption group showed an increased risk of composite adverse outcomes [adjusted hazard ratio (aHR) 1.32, 95% confidence interval (CI) 1.06-1.66] compared with the reference group (abstainer-rare group). However, no significant increased risk for adverse outcomes was observed in the light (aHR 0.88, 95% CI 0.68-1.13) and moderate (aHR 0.91, 95% CI 0.63-1.33) groups. In subgroup analyses, adverse effect of heavy alcohol consumption was significant, especially among patients with low CHA2DS2-VASc score, without hypertension, and in whom β-blocker were not prescribed.

Conclusion: Our findings suggest that heavy alcohol consumption increases the risk of adverse events in patients with AF, whereas light or moderate alcohol consumption does not.

Keywords: Alcohol consumption; Atrial fibrillation; Heavy drinking; Hospitalization; Registry; Stroke.
Author(s)
강기원김준김진배김태훈박준범박진규박형욱심재민엄재선유희태이소영이영수이정명임채완정보영차명진최의근
Issued Date
2021
Type
Article
Keyword
Alcohol consumptionAtrial fibrillationHeavy drinkingHospitalizationRegistryStroke
DOI
10.1093/europace/euaa340
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7219
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2464146447&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Effect%20of%20alcohol%20consumption%20on%20the%20risk%20of%20adverse%20events%20in%20atrial%20fibrillation:%20from%20the%20COmparison%20study%20of%20Drugs%20for%20symptom%20control%20and%20complication%20prEvention%20of%20Atrial%20Fibrillation%20(CODE-AF)%20registry&amp;offset=0&amp;pcAvailability=true
Publisher
EUROPACE
Location
미국
Language
영어
ISSN
1099-5129
Citation Volume
23
Citation Number
4
Citation Start Page
548
Citation End Page
556
Appears in Collections:
Medicine > Medicine
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