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Long-Term (7-Year) Clinical Implications of Newly Unveiled Asymptomatic Abnormal Ankle-Brachial Index in Patients With Coronary Artery Disease

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Abstract
Background The long-term impact of newly discovered, asymptomatic abnormal ankle-brachial index (ABI) in patients with significant coronary artery disease is limited. Methods and Results Between January 2006 and December 2009, ABI was evaluated in 2424 consecutive patients with no history of claudication or peripheral artery disease who had significant coronary artery disease. We previously reported a 3-year result; therefore, the follow-up period was extended. The primary end point was a composite of all-cause death, myocardial infarction (MI), and stroke over 7 years. Of the 2424 patients with significant coronary artery disease, 385 had an abnormal ABI (ABI <= 0.9 or >= 1.4). During the follow-up period, the rate of the primary outcome was significantly higher in the abnormal ABI group than in the normal ABI group (P<0.001). The abnormal ABI group had a significantly higher risk of composite of all-cause death/MI/stroke than the normal ABI group, after adjustment with multivariable Cox proportional hazards regression analysis (hazard ratio [HR], 2.07; 95% CI, 1.67-2.57; P<0.001) and propensity score-matched analysis (HR, 1.97; 95% CI, 1.49-2.60; P<0.001). In addition, an abnormal ABI was associated with a higher risk of all-cause death, MI, and stroke, but not repeat revascularization. Conclusions Among patients with significant coronary artery disease, asymptomatic abnormal ABI was associated with sustained and increased incidence of composite of all-cause death/MI/stroke, all-cause death, MI, and stroke during extended follow-up over 7 years.
Author(s)
강수진김영학김주형김태오박성욱박한빛양유진이승재이승환이정훈이종영이철환이필형정용진현준호
Issued Date
2021
Type
Article
Keyword
Ankle Brachial IndexCause of DeathCoronary Artery Disease - epidemiologyCoronary Artery Disease - physiopathologyFollow-Up StudiesHumansMyocardial Infarction - epidemiologyPredictive Value of TestsRisk FactorsStroke - epidemiology
DOI
10.1161/JAHA.121.021587
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7227
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2580940606&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Long-Term%20(7-Year)%20Clinical%20Implications%20of%20Newly%20Unveiled%20Asymptomatic%20Abnormal%20Ankle-Brachial%20Index%20in%20Patients%20With%20Coronary%20Artery%20Disease&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Location
미국
Language
한국어
ISSN
2047-9980
Citation Volume
10
Citation Number
20
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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