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Clinical characteristics and outcomes of Korean patients with sarcoidosis

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Abstract
Sarcoidosis is a systemic granulomatous disorder of unknown cause involving multiple organs. Its clinical presentation and prognosis vary among races. We identified the clinical characteristics and outcomes of Korean patients with sarcoidosis. Clinical data of 367 Korean patients with biopsy-proven sarcoidosis diagnosed in 2001-2017 were retrospectively analyzed. Treatment responses included improvement, stability, or progression based on changes in pulmonary sarcoidosis on chest images. The mean age was 47.4 years, and 67.3% of patients were women. The median follow-up period was 80 months. The highest prevalence was observed in individuals aged 50-59 years (30-39 years in men, 50-59 years in women), and the number of diagnoses showed an increasing trend. Lung involvement was the most common (93.5%), followed by the skin, eyes, and extrathoracic lymph nodes. Among patients with lung involvement and a follow-up period of ≥ 3 months, 66.8%, 31.0%, and 2.2% showed improvement, stability, and progression, respectively. Eleven patients (2.9%) died, and the 5-year survival rate was 99%. The number of diagnosed cases showed an increasing trend, and the mean age at diagnosis was increased compared with that in previous reports. Organ involvement was similar to that of Westerners, although the prognosis appeared better.
Author(s)
송진우Ho Jeong KimHyeong Min Kim
Issued Date
2021
Type
Article
Keyword
AdultAgedBiopsyDisease ManagementDisease SusceptibilityFemaleHumansKaplan-Meier EstimateLymph nodesMaleMedical prognosisMiddle AgedOrgan SpecificityPatient Outcome AssessmentPatientsPrognosisPublic Health Surveillance RegistriesRepublic of Korea - epidemiologySarcoidosisSarcoidosis - diagnosisSarcoidosis - epidemiologySarcoidosis - etiologySarcoidosis - mortalitySeverity of Illness IndexSymptom Assessment
DOI
10.1038/s41598-021-03175-1
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7238
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_a7b54fe5d8cf4c008d15c1226144434b&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinical%20characteristics%20and%20outcomes%20of%20Korean%20patients%20with%20sarcoidosis&offset=0&pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
영국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
23700
Citation End Page
23700
Appears in Collections:
Medicine > Medicine
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