Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation
- Abstract
- We sought to evaluate the clinical implication of LAE based on left atrial anterior-posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14-2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23-2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09-2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
- Author(s)
- 강기원; 김준; 김진배; 김창수; 김태훈; 박준범; 박진규; 박형섭; 박형욱; 심재민; 엄재순; 이소령; 이영수; 이정명; 정보영; 조민수; 차명진; 최의균
- Issued Date
- 2021
- Type
- Article
- Keyword
- Aged; Atrial Fibrillation - complications; Atrial Fibrillation - diagnosis; Atrial Fibrillation - epidemiology; Atrial Fibrillation - therapy; Biomarkers; Cardiac arrhythmia; Cardiomegaly - diagnosis; Cardiomegaly - epidemiology; Cardiomegaly - etiology; Comorbidity; Disease Susceptibility; Echocardiography; Embolism; Female; Fibrillation; Heart Atria - pathology; Heart Atria - physiopathology; Heart Function Tests; Humans; Male; Middle Aged; Patient Acuity; Patients; Public Health Surveillance; Registries; Republic of Korea - epidemiology
- DOI
- 10.1038/s41598-021-03266-z
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7239
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_f75de450fc7540148c45728dbd0e3fb7&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinical%20impact%20of%20left%20atrial%20enlargement%20in%20Korean%20patients%20with%20atrial%20fibrillation&offset=0&pcAvailability=true
- Publisher
- SCIENTIFIC REPORTS
- Location
- 미국
- Language
- 영어
- ISSN
- 2045-2322
- Citation Volume
- 11
- Citation Number
- 1
- Citation Start Page
- 23808
- Citation End Page
- 23808
-
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