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Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation

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Abstract
We sought to evaluate the clinical implication of LAE based on left atrial anterior-posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14-2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23-2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09-2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
Author(s)
강기원김준김진배김창수김태훈박준범박진규박형섭박형욱심재민엄재순이소령이영수이정명정보영조민수차명진최의균
Issued Date
2021
Type
Article
Keyword
AgedAtrial Fibrillation - complicationsAtrial Fibrillation - diagnosisAtrial Fibrillation - epidemiologyAtrial Fibrillation - therapyBiomarkersCardiac arrhythmiaCardiomegaly - diagnosisCardiomegaly - epidemiologyCardiomegaly - etiologyComorbidityDisease SusceptibilityEchocardiographyEmbolismFemaleFibrillationHeart Atria - pathologyHeart Atria - physiopathologyHeart Function TestsHumansMaleMiddle AgedPatient AcuityPatientsPublic Health SurveillanceRegistriesRepublic of Korea - epidemiology
DOI
10.1038/s41598-021-03266-z
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7239
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_f75de450fc7540148c45728dbd0e3fb7&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Clinical%20impact%20of%20left%20atrial%20enlargement%20in%20Korean%20patients%20with%20atrial%20fibrillation&offset=0&pcAvailability=true
Publisher
SCIENTIFIC REPORTS
Location
미국
Language
영어
ISSN
2045-2322
Citation Volume
11
Citation Number
1
Citation Start Page
23808
Citation End Page
23808
Appears in Collections:
Medicine > Medicine
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