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Behavioral interventions to reduce particulate matter exposure in patients with COPD

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Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is commonly affected by particulate matter (PM) exposure. In this study, we aimed to evaluate whether behavioral interventions to reduce PM exposure improve clinical outcomes in patients with COPD. Methods: A multicenter randomized controlled trial will be conducted involving 120 participants recruited from 3 hospitals in the capital region of the Republic of Korea. Patients aged 40 to 80 years with a diagnosis of COPD and a forced expiratory volume at 1 s <80% of the predicted value are eligible for inclusion. The participants will be randomized to either the intervention group or the usual care group (2:1). The behavioral interventions will comprise the following activities: checking air quality forecast; operating indoor air cleaners and regular check-ups of filters; ventilating the home regularly by opening windows; adhering to inhaler treatment; and refraining from going out on high air pollution days. "Internet-of-things"-based, gravimetric, and light-scattering methods will be used to measure indoor and outdoor PM concentrations. To estimate the degree of individual PM exposure, a time-activity diary and land use regression modeling will be used. The efficacy of the behavioral interventions on the following outcomes will be analyzed: amount of PM exposure, changes in forced expiratory volume at 1 s from the baseline, changes in respiratory symptoms and quality of life, risks of exacerbation, hospitalization, and death. Discussion: Given the harmful effect of air pollutants, individual-level interventions to reduce exposure may be significant. However, there is a lack of evidence on how effective such interventions are to date. This study will be able to provide physicians and patients with evidence-based strategies to reduce PM exposure in daily life.
Author(s)
이세원Hwan-Cheol KimHyun Woo JiJi Ye JungJieun KangJin-Young Huh
Issued Date
2021
Type
Article
Keyword
AdultAir Pollutants - analysisAir Pollution - anaylsisEnvironmental MonitoringFemaleHumansMaleParticulate Matter - adverse effecctsParticulate Matter - analysisPulmonary DiseaseChronic Obstructive - therapyQuality of lifeRepublic of Korea
DOI
10.1097/MD.0000000000028119
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7245
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1097_MD_0000000000028119&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Behavioral%20interventions%20to%20reduce%20particulate%20matter%20exposure%20in%20patients%20with%20COPD&amp;offset=0&amp;pcAvailability=true
Publisher
MEDICINE
Location
미국
Language
영어
ISSN
0025-7974
Citation Volume
100
Citation Number
49
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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