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Effect of antiviral therapy in patients with low HBV DNA level on transarterial chemoembolization for hepatocellular carcinoma

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Abstract
Antiviral therapy improves survival in patients with hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). However, the effect of antiviral therapy in patients with low-level viremia HBV-HCC receiving non-curative therapy remains unclear. We aimed to evaluate the role of antiviral therapy in patients with low-level viremia and treated with transarterial chemoembolization (TACE). This retrospective study evaluated 206 patients with HBV-HCC who underwent TACE as an initial treatment. Of those, 135 patients received antiviral therapy (antiviral group), and 71 did not (non-antiviral group). The definition of low-level viremia was an HBV DNA level <2000 IU/ml. Kaplan-Meier curves, log-rank tests and Cox regression analysis were used for statistical analyses. The median follow-up duration was 39 months (1-174 months). Overall survival (OS) did not differ between groups (P = .227). Barcelona Clinic Liver Cancer stage (BCLC), Child-Pugh (CP) class and alpha-fetoprotein level were independent prognostic factors for OS. Antiviral therapy (hazard ratio [HR], 0.503, P = .022) was a prognostic factor for 2-year survival. On subgroup analysis, antiviral therapy improved short-term survival in patients with BCLC stage 0 and A (P = .037) and CP class A (P = .04). In patients with low-level viremia, antiviral therapy yielded short-term survival benefits, particularly in patients with early-stage HCC.
Author(s)
KIMMPYangJKJunBG김영돈천갑진JungHJYooJJJeongSWJangJYKimHSLeeSH
Issued Date
2021
Type
Article
Keyword
antiviral therapychemoembolizationhepatitis B virushepatocellular carcinomasurvival
DOI
10.1111/jvh.13508
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7248
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2504772670&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Effect%20of%20antiviral%20therapy%20in%20patients%20with%20low%20HBV%20DNA%20level%20on%20transarterial%20chemoembolization%20for%20hepatocellular%20carcinoma&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF VIRAL HEPATITIS
Location
미국
Language
영어
ISSN
1352-0504
Citation Volume
28
Citation Number
7
Citation Start Page
1011
Citation End Page
1018
Appears in Collections:
Medicine > Medicine
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