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The longitudinal outcomes of applying non-selective beta-blockers in portal hypertension: real-world multicenter study

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Abstract
Background/Aim We investigated the effect of non-selective beta-blockers (NSBB) in real-world situations and whether low-dose NSBB is beneficial compared to maximally tolerated doses. Methods We performed a retrospective study of 740 patients with cirrhosis requiring prophylactic treatment of esophageal varices: 473 primary prophylaxis (PP: NSBB = 349, non-NSBB = 124) and 267 secondary prophylaxis (SP: NSBB = 200, non-NSBB = 67). The NSBB group was divided into low-dose (<= 80 mg/day) and high-dose (> 80 mg/day). Results In the PP group, NSBB treatment reduced mortality and showed the most pronounced effect in patients with moderate/severe ascites (hazard ratio [HR], 0.46; p < 0.01), HVPG >= 16 mmHg (HR, 0.53; p = 0.04), or CTP class B/C (HR, 0.46; p < 0.01) but not in those with no/mild ascites, HVPG < 16 mmHg, or CTP class A. Low-dose NSBB group showed a significant reduction in mortality compared with non-NSBB (moderate/severe ascites: HR, 0.61; p = 0.02 and CTP class B/C: HR, 0.41; p < 0.01) and the effect size was stronger than the high-dose NSBB. NSBB was associated with a reduced risk of infection (HR, 0.36; p = 0.01). In the SP group, NSBB prolonged survival in patients with moderate/severe ascites (HR, 0.56; p = 0.02), HVPG >= 16 mmHg (HR, 0.42; p < 0.01), or CTP class B/C (HR, 0.52; p < 0.01). Low-dose NSBB was more beneficial with 56% risk reduction (p < 0.01) of mortality compared with 33% risk reduction in the high-dose NSBB (p = 0.05). Conclusion NSBB therapy was associated with longer survival in PP and SP groups who had an advanced stage of cirrhosis. Moreover, low-dose NSBB exhibited a better benefit than a standard-titrated high-dose NSBB with better tolerability.
Author(s)
Kang SHLee MJKim MYLee JHJun BGKim TSChoi DHSuk KT김영돈천갑진Kim DJBaik SK
Issued Date
2021
Type
Article
Keyword
nonselective β-blockersliver cirrhosissurvivalportal hypertensiontreatmentesophageal varixhepatic venous pressure gradientlow-dose non-selective β-blockersascitesseverity
DOI
10.1007/s12072-021-10160-3
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7251
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2514605109&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,The%20longitudinal%20outcomes%20of%20applying%20non-selective%20beta-blockers%20in%20portal%20hypertension:%20real-world%20multicenter%20study&amp;offset=0&amp;pcAvailability=true
Publisher
HEPATOLOGY INTERNATIONAL
Location
스위스
Language
영어
ISSN
1936-0533
Citation Volume
15
Citation Number
2
Citation Start Page
424
Citation End Page
436
Appears in Collections:
Medicine > Medicine
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