Right Ventricular Assist Device With Extracorporeal Membrane Oxygenation for Bridging Right Ventricular Heart Failure to Lung Transplantation: A Single-Center Case Series and Literature Review

Abstract

-----------e-pub (22.1.19)------------ Objective: Right ventricular heart failure (RVHF) is a critical complication in patients with respiratory failure, particularly among those who transitioned to lung transplantation using venovenous (VV) extracorporeal membrane oxygenation (ECMO). In these patients, both cardiac and respiratory functions are supported using venoarterial or venoarterial-venous ECMO. However, these modalities increase the risk of device-related complications, such as thromboembolism, bleeding, and limb ischemia, and they may disturb early rehabilitation. Due to these limitations, a right ventricular assist device with an oxygenator (Oxy-RVAD) using ECMO may be considered for patients with RVHF with VV ECMO.

Design: A retrospective case series and literature review.

Setting: A single tertiary care university hospital.

Participants: The study comprised lung transplantation candidates on ECMO bridging who developed right-sided heart failure.

Interventions: An RVAD with ECMO.

Measurements and main results: Of eight patients who underwent the study protocol, seven were bridged successfully to lung transplantation (BTT), and all patients with BTT were discharged, with a 30-day survival rate of 100% (7/7 patients). The 180-day survival rate was 85% (6/7 patients).

Conclusions: The study suggested that Oxy-RVAD using ECMO may be a viable option for bridging patients with RVHF to lung transplantation.

Trial registration: Retrospectively registered.

Keywords: extracorporeal membrane oxygenation; lung transplantation; right ventricular assist device; right ventricular heart failure.