Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion
- Abstract
- Curcumin (diferuloylmethane) is a major component of turmeric, which is isolated from the rhizomes of Curcuma longa L. from the family Zingiberaceae. It is used as a dietary pigment for curry and in traditional Indian medicine for its anti-inflammatory and attenuating pain effects. This study aimed to evaluate the beneficial effects of curcumin in a rat model of diabetic neuropathic pain. Additionally, we investigated the involvement of the phosphorylated form of c-Jun N-terminal kinase (pJNK) located in the neurons and astrocytes of the dorsal root ganglion (DRG). To induce diabetic neuropathic pain in rats, 50 mg/kg of streptozotocin (STZ) was intraperitoneally injected. After 4 weeks, rats were administered the vehicle, 10 mg/kg/day curcumin, or 50 mg/kg/day curcumin orally for 4 consecutive weeks. One day after the final drug administration, we performed behavioral tests to measure responses of rats to mechanical, heat, cold, and acetone-induced cold stimuli. After behavioral tests, pJNK expression in the DRG was evaluated using western blot assay and immunohistochemistry. Curcumin treatment for 4 consecutive weeks in STZ-induced diabetic neuropathic pain rats improved behavioral responses to mechanical, cold, and thermal stimuli. Increased pJNK expression in the astrocytes and neurons of the DRG in STZ-induced diabetic neuropathic pain rats was reduced by curcumin treatment for 4 consecutive weeks. We suggest that curcumin can be an option for the treatment of diabetes-related neuropathic pain, and one of the mechanisms that underlie the action of curcumin may involve pJNK expression in the astrocytes and neurons of the DRG.
- Author(s)
- 박지훈; 박한울; 심지훈; 이종혁; 임정길; 최성수
- Issued Date
- 2021
- Type
- Article
- Keyword
- Analgesics; Antibodies; Cold; Diabetes; Diabetic neuropathy; Experiments; Kinases; Laboratory animals; Pain; Proteins; Rodents; Software; Tumor necrosis factor-TNF; Variance analysis
- DOI
- 10.1155/2021/8787231
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7257
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_b892c3c0a1c84869b9873d333242045f&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20Curcumin%20Treatment%20in%20a%20Diabetic%20Neuropathic%20Pain%20Model%20of%20Rats:%20Involvement%20of%20c-Jun%20N-Terminal%20Kinase%20Located%20in%20the%20Astrocytes%20and%20Neurons%20of%20the%20Dorsal%20Root%20Ganglion&offset=0&pcAvailability=true
- Publisher
- PAIN RESEARCH MANAGEMENT
- Location
- 영국
- Language
- 영어
- ISSN
- 1203-6765
- Citation Volume
- 2021
- Citation Number
- 2021
- Citation Start Page
- 0
- Citation End Page
- 0
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