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Effects of Curcumin Treatment in a Diabetic Neuropathic Pain Model of Rats: Involvement of c-Jun N-Terminal Kinase Located in the Astrocytes and Neurons of the Dorsal Root Ganglion

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Abstract
Curcumin (diferuloylmethane) is a major component of turmeric, which is isolated from the rhizomes of Curcuma longa L. from the family Zingiberaceae. It is used as a dietary pigment for curry and in traditional Indian medicine for its anti-inflammatory and attenuating pain effects. This study aimed to evaluate the beneficial effects of curcumin in a rat model of diabetic neuropathic pain. Additionally, we investigated the involvement of the phosphorylated form of c-Jun N-terminal kinase (pJNK) located in the neurons and astrocytes of the dorsal root ganglion (DRG). To induce diabetic neuropathic pain in rats, 50 mg/kg of streptozotocin (STZ) was intraperitoneally injected. After 4 weeks, rats were administered the vehicle, 10 mg/kg/day curcumin, or 50 mg/kg/day curcumin orally for 4 consecutive weeks. One day after the final drug administration, we performed behavioral tests to measure responses of rats to mechanical, heat, cold, and acetone-induced cold stimuli. After behavioral tests, pJNK expression in the DRG was evaluated using western blot assay and immunohistochemistry. Curcumin treatment for 4 consecutive weeks in STZ-induced diabetic neuropathic pain rats improved behavioral responses to mechanical, cold, and thermal stimuli. Increased pJNK expression in the astrocytes and neurons of the DRG in STZ-induced diabetic neuropathic pain rats was reduced by curcumin treatment for 4 consecutive weeks. We suggest that curcumin can be an option for the treatment of diabetes-related neuropathic pain, and one of the mechanisms that underlie the action of curcumin may involve pJNK expression in the astrocytes and neurons of the DRG.
Author(s)
박지훈박한울심지훈이종혁임정길최성수
Issued Date
2021
Type
Article
Keyword
AnalgesicsAntibodiesColdDiabetesDiabetic neuropathyExperimentsKinasesLaboratory animalsPainProteinsRodentsSoftwareTumor necrosis factor-TNFVariance analysis
DOI
10.1155/2021/8787231
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7257
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_b892c3c0a1c84869b9873d333242045f&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20Curcumin%20Treatment%20in%20a%20Diabetic%20Neuropathic%20Pain%20Model%20of%20Rats:%20Involvement%20of%20c-Jun%20N-Terminal%20Kinase%20Located%20in%20the%20Astrocytes%20and%20Neurons%20of%20the%20Dorsal%20Root%20Ganglion&offset=0&pcAvailability=true
Publisher
PAIN RESEARCH MANAGEMENT
Location
영국
Language
영어
ISSN
1203-6765
Citation Volume
2021
Citation Number
2021
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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