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Predictors Associated with Outcomes of Epidural Blood Patch in Patients with Spontaneous Intracranial Hypotension

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Abstract
An autologous epidural blood patch (EBP) is a mainstay of treatment in patients with spontaneous intracranial hypotension (SIH). EBP, however, is less effective for SIH than post-dural puncture headaches. Therefore, patients with SIH frequently require an additional EBP. The aim of this study was to identify factors associated with poor response to EBP. This single-center retrospective observational study used the institutional registry records of 321 patients who underwent EBP between September 2001 and March 2016. Patients were divided into two groups, a poor responder group, consisting of patients who underwent EBP at least three times or more, and a good responder group of patients who experienced sufficient symptom relief after two or fewer EBP. The demographic characteristics, clinical features, radiologic findings, procedural data, and laboratory data were analyzed. Univariate analysis showed that the neutrophil-to-lymphocyte ratio (NLR; p = 0.004) and platelet-to-lymphocyte ratio (p = 0.015) were significantly lower in poor than in good responders. Multivariate analysis found that NLR was the only independent factor associated with a poor response (odds ratio = 0.720; p = 0.008). These findings indicate that a low NLR was associated with three or more EBP administrations for the sufficient improvement of symptoms in patients with SIH.
Author(s)
노영진박준영신진우오율임정길최성수
Issued Date
2021
Type
Article
Keyword
epidural blood patchneutrophil-to-lymphocyte ratiospontaneous intracranial hypotension
DOI
10.3390/jcm10050922
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7264
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_cb75586cb094438ca425b3434e152668&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Predictors%20Associated%20with%20Outcomes%20of%20Epidural%20Blood%20Patch%20in%20Patients%20with%20Spontaneous%20Intracranial%20Hypotension&offset=0&pcAvailability=true
Publisher
JOURNAL OF CLINICAL MEDICINE
Location
스위스
Language
영어
ISSN
2077-0383
Citation Volume
10
Citation Number
5
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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