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Rupture Risk of Intracranial Aneurysm and Prediction of Hemorrhagic Stroke after Liver Transplant

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Abstract
Postoperative hemorrhagic stroke (HS) is a rare yet devastating complication after liver transplantation (LT). Unruptured intracranial aneurysm (UIA) may contribute to HS; however, related data are limited. We investigated UIA prevalence and aneurysmal subarachnoid hemorrhage (SAH) and HS incidence post-LT. We identified risk factors for 1-year HS and constructed a prediction model. This study included 3544 patients who underwent LT from January 2008 to February 2019. Primary outcomes were incidence of SAH, HS, and mortality within 1-year post-LT. Propensity score matching (PSM) analysis and Cox proportional hazard analysis were performed. The prevalence of UIAs was 4.63% (n = 164; 95% confidence interval (CI), 3.95-5.39%). The 1-year SAH incidence was 0.68% (95% CI, 0.02-3.79%) in patients with UIA. SAH and HS incidence and mortality were not different between those with and without UIA before and after PSM. Cirrhosis severity, thrombocytopenia, inflammation, and history of SAH were identified as risk factors for 1-year HS. UIA presence was not a risk factor for SAH, HS, or mortality in cirrhotic patients post-LT. Given the fatal impact of HS, a simple scoring system was constructed to predict 1-year HS risk. These results enable clinical risk stratification of LT recipients with UIA and help assess perioperative HS risk before LT.
Author(s)
권혜미전인구김경선문영진허인영이정민송준걸황규삼
Issued Date
2021
Type
Article
Keyword
end-stage liver diseaseintracranial aneurysmintracranial hemorrhagemortalityprediction
DOI
10.3390/brainsci11040445
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7274
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_e080735b79ca48bbbd6f72bb30113992&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Rupture%20Risk%20of%20Intracranial%20Aneurysm%20and%20Prediction%20of%20Hemorrhagic%20Stroke%20after%20Liver%20Transplant&offset=0&pcAvailability=true
Publisher
BRAIN SCIENCES
Location
스위스
Language
영어
ISSN
2076-3425
Citation Volume
11
Citation Number
4
Citation Start Page
445
Citation End Page
445
Appears in Collections:
Medicine > Medicine
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