KLI

Low Preoperative Antithrombin III Level Is Associated with Postoperative Acute Kidney Injury after Liver Transplantation

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Abstract
We aimed to determine the association between the preoperative antithrombin III (ATIII) level and postoperative acute kidney injury (AKI) after LT (post-LT AKI). We retrospectively evaluated 2395 LT recipients between 2010 and 2018 whose data of perioperative ATIII levels were available. Patients were divided into two groups based on the preoperative level of ATIII (ATIII < 50% vs. ATIII >= 50%). Multivariable regression analysis was performed to assess the risk factors for post-LT AKI. The mean preoperative ATIII levels were 30.2 +/- 11.8% in the ATIII < 50% group and 67.2 +/- 13.2% in the ATIII >= 50% group. The incidence of post-LT AKI was significantly lower in the ATIII >= 50% group compared to that in the ATIII < 50% group (54.7% vs. 75.5%, p < 0.001); odds ratio (OR, per 10% increase in ATIII level) 0.86, 95% confidence interval (CI) 0.81-0.92; p < 0.001. After a backward stepwise regression model, female sex, high body mass index, low albumin, deceased donor LT, longer duration of surgery, and high red blood cell transfusion remained significantly associated with post-LT AKI. A low preoperative ATIII level is associated with post-LT AKI, suggesting that preoperative ATIII might be a prognostic factor for predicting post-LT AKI.
Author(s)
김경선문영진김성훈김보미전인구권혜미송준걸황규삼
Issued Date
2021
Type
Article
Keyword
acute kidney injuryantithrombinliver transplantation
DOI
10.3390/jpm11080716
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7285
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_bc26c733a4a349b8ba2c66f24390e592&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Low%20Preoperative%20Antithrombin%20III%20Level%20Is%20Associated%20with%20Postoperative%20Acute%20Kidney%20Injury%20after%20Liver%20Transplantation&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF PERSONALIZED MEDICINE
Location
스위스
Language
영어
ISSN
2075-4426
Citation Volume
11
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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