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Association between Neutrophil-Lymphocyte Ratio and Herpes Zoster Infection in 1688 Living Donor Liver Transplantation Recipients at a Large Single Center

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Abstract
Liver transplantation (LT) is closely associated with decreased immune function, a contributor to herpes zoster (HZ). However, risk factors for HZ in living donor LT (LDLT) remain unknown. Neutrophil-lymphocyte ratio (NLR) and immune system function are reportedly correlated. This study investigated the association between NLR and HZ in 1688 patients who underwent LDLT between January 2010 and July 2020 and evaluated risk factors for HZ and postherpetic neuralgia (PHN). The predictive power of NLR was assessed through the concordance index and an integrated discrimination improvement (IDI) analysis. Of the total cohort, 138 (8.2%) had HZ. The incidence of HZ after LT was 11.2 per 1000 person-years and 0.1%, 1.3%, 2.9%, and 13.5% at 1, 3, 5, and 10 years, respectively. In the Cox regression analysis, preoperative NLR was significantly associated with HZ (adjusted hazard ratio [HR], 1.05; 95% confidence interval [CI], 1.02-1.09; p = 0.005) and PHN (HR, 1.08; 95% CI, 1.03-1.13; p = 0.001). Age, sex, mycophenolate mofetil use, and hepatitis B virus infection were risk factors for HZ versus age and sex for PHN. In the IDI analysis, NLR was discriminative for HZ and PHN (p = 0.020 and p = 0.047, respectively). Preoperative NLR might predict HZ and PHN in LDLT recipients.
Author(s)
심지훈문영진김성훈김경선이주승송준걸황규삼
Issued Date
2021
Type
Article
Keyword
herpes zosterliver transplantationliving donorneutrophil-lymphocyte ratiopostherpetic
DOI
10.3390/biomedicines9080963
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7288
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_227d3bc043a34cbd9318dfdb67d88d1d&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Association%20between%20Neutrophil-Lymphocyte%20Ratio%20and%20Herpes%20Zoster%20Infection%20in%201688%20Living%20Donor%20Liver%20Transplantation%20Recipients%20at%20a%20Large%20Single%20Center&offset=0&pcAvailability=true
Publisher
BIOMEDICINES
Location
스위스
Language
영어
ISSN
2227-9059
Citation Volume
9
Citation Number
8
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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