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Low Preoperative Lymphocyte-to-Monocyte Ratio Is Predictive of the 5-Year Recurrence of Bladder Tumor after Transurethral Resection

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Abstract
Many studies have investigated the prognostic significance of peripheral blood parameters-including lymphocyte-to-monocyte ratio (LMR)-in several cancers in recent decades. We evaluated the prognostic factors for five-year tumor recurrence after the transurethral resection of a bladder tumor (TURBT). In total, 151 patients with non-muscle invasive bladder tumors who underwent TURBT under spinal anesthesia were selected for this retrospective analysis. The time to tumor recurrence was determined by the number of days from surgery until there was a pathological confirmation of tumor recurrence. The preoperative and postoperative laboratory values were defined as results within one month prior to and one month after TURBT. Univariate and multivariate Cox regression analyses were performed. Seventy-one patients (47.0%) developed recurrent bladder tumors within five years after the first TURBT surgery. The multivariate Cox regression analysis revealed that preoperative LMR (hazard ratio, 0.839; 95% confidence interval, 0.739-0.952; p = 0.006) and multiple tumor sites (hazard ratio, 2.072; 95% confidence interval, 1.243-3.453; p = 0.005) were independent recurrence predictors in patients with recurrent bladder tumors within five years after the TURBT. A low preoperative LMR is an important predictor for the recurrence of a bladder tumor during a five-year follow-up period after surgery.
Author(s)
김경미유지현박준영백성운황재현최우종김영국
Issued Date
2021
Type
Article
Keyword
bladder tumorlymphocyte-to-monocyte ratioperipheral blood parameterstumor recurrencetransurethral resection
DOI
10.3390/jpm11100947
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7292
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_be41ae7c48ed476097ff27cc9ca4fb72&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Low%20Preoperative%20Lymphocyte-to-Monocyte%20Ratio%20Is%20Predictive%20of%20the%205-Year%20Recurrence%20of%20Bladder%20Tumor%20after%20Transurethral%20Resection&offset=0&pcAvailability=true
Publisher
JOURNAL OF PERSONALIZED MEDICINE
Location
스위스
Language
영어
ISSN
2075-4426
Citation Volume
11
Citation Number
10
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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