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Comparison of human peripheral blood dendritic cell activation by four fucoidans

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Abstract
Brown seaweed is an important source of fucoidan, which displays immunomodulatory effects by activating various immune cells. However, these effects of fucoidans from various sources of brown seaweed have not yet been explored in human blood dendritic cells. We studied fucoidans extracted from Ecklonia cava, Macrocystis pyrifera, Undaria pinnatifida, and Fucus vesiculosus for their effects on human monocyte-derived dendritic cells (MODC) and human peripheral blood DC (PBDC) activation. Ecklonia cava fucoidan (ECF) strongly upregulated co-stimulatory molecules, major histocompatibility complex class I and II, and the production of proinflammatory cytokines in MODCs and PBDCs compared to those by the other three fucoidans. Moreover, ECF elicited the strongest effect in the induction of syngeneic T cell proliferation and IFN-γ production compared to those of other fucoidans. These results suggest that ECF could be a suitable candidate molecule for enhancing immune activation in humans compared to that with the other three fucoidans.
Author(s)
Wei ZhangHae-Bin ParkDhananjay YadavJuyoung HwangEun-Koung AnHee-Yun EomSo-Jung KimMinseok Kwak이창환Jun-O Jin
Issued Date
2021
Type
Article
Keyword
Dencritic CellImmunotherapycancerimmunomodulatory
DOI
10.1016/j.ijbiomac.2021.01.155
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7301
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2483817426&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Comparison%20of%20human%20peripheral%20blood%20dendritic%20cell%20activation%20by%20four%20fucoidans&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Location
네덜란드
Language
한국어
ISSN
0141-8130
Citation Volume
174
Citation Number
174
Citation Start Page
477
Citation End Page
484
Appears in Collections:
Medicine > Medicine
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