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Harnessing NK cells for cancer immunotherapy: immune checkpoint receptors and chimeric antigen receptors

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Abstract
Natural killer (NK) cells, key antitumor effectors of the innate immune system, are endowed with the unique ability to spontaneously eliminate cells undergoing a neoplastic transformation. Given their broad reactivity against diverse types of cancer and close association with cancer prognosis, NK cells have gained considerable attention as a promising therapeutic target for cancer immunotherapy. NK cell-based therapies have demonstrated favorable clinical efficacies in several hematological malignancies but limited success in solid tumors, thus highlighting the need to develop new therapeutic strategies to restore and optimize anti-tumor activity while preventing tumor immune escape. The current therapeutic modalities yielding encouraging results in clinical trials include the blockade of immune checkpoint receptors to overcome the immune-evasion mechanism used by tumors and the incorporation of tumor-directed chimeric antigen receptors to enhance NK cell anti-tumor specificity and activity. These observations, together with recent advances in the understanding of NK cell activation within the tumor microenvironment, will facilitate the optimal design of NK cell-based therapy against a broad range of cancers and, more desirably, refractory cancers.
Author(s)
김나영최우선이동희이은비김효정김정민진형승김헌식
Issued Date
2021
Type
Article
Keyword
NK cellImmune checkpoint inhibitorChimeric antigen receptor
DOI
10.5483/BMBRep.2021.54.1.214
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7302
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9709546&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Harnessing%20NK%20cells%20for%20cancer%20immunotherapy:%20immune%20checkpoint%20receptors%20and%20chimeric%20antigen%20receptors&sortby=rank
Publisher
BMB REPORTS
Location
대한민국
Language
영어
ISSN
1976-6696
Citation Volume
54
Citation Number
1
Citation Start Page
44
Citation End Page
58
Appears in Collections:
Medicine > Medicine
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