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Ecklonia cava fucoidan has potential to stimulate natural killer cells in vivo

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Abstract
Fucoidan is a sulfated polysaccharide, derived from various marine brown seaweeds, that has immunomodulatory effects. In this study, we analyzed the effects of five different fucoidans, which were extracted from Ascophyllum nodosum, Undaria pinnatifida, Macrocystis pyrifera, Fucus vesiculosus, and Ecklonia cava, on natural killer (NK) cell activation in mice. Among these, E. cava fucoidan (ECF) promoted an increase in the number of NK cells in the spleen and had the strongest effect on the activation of NK cells. Additionally, we observed that DC stimulation was required for NK cell activation and that ECF had the most potent effect on splenic dendritic cells (DC). Finally, ECF treatment effectively prevented infiltration of CT-26 carcinoma cells in the lungs of BALB/c mice in an NK cell dependent manner. Collectively, these results suggest that ECF could be a suitable candidate for enhancing NK cell-mediated anti-cancer immunity.
Author(s)
Wei ZhangEun-Koung AnHae-Bin ParkJuyoung HwangYadav DhananjaySo-Jung KimHee-Yun EomTatsuya OdaMinseok Kwak이창환Jun-O Jin
Issued Date
2021
Type
Article
Keyword
fucoidanSplenic natural killer cellCytotoxicityAnti-tumor effect
DOI
10.1016/j.ijbiomac.2021.06.045
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7315
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2540719740&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Ecklonia%20cava%20fucoidan%20has%20potential%20to%20stimulate%20natural%20killer%20cells%20in%20vivo&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Location
네덜란드
Language
한국어
ISSN
0141-8130
Citation Volume
185
Citation Number
185
Citation Start Page
111
Citation End Page
121
Appears in Collections:
Medicine > Medicine
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