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Assessment of naive indolent lymphoma using whole-body diffusion-weighted imaging and T2-weighted MRI: results of a prospective study in 30 patients

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Abstract
BackgroundWe prospectively evaluated the diagnostic utility of whole-body diffusion-weighted imaging with background body signal suppression and T2-weighted short-tau inversion recovery MRI (WB-DWIBS/STIR) for the pretherapeutic staging of indolent lymphoma in 30 patients.MethodsThis prospective study included 30 treatment-naive patients with indolent lymphomas who underwent WB-DWIBS/STIR and conventional imaging workup plus biopsy. The pretherapeutic staging agreement, sensitivity, and specificity of WB-DWIBS/STIR were investigated with reference to the multimodality and multidisciplinary consensus review for nodal and extranodal lesions excluding bone marrow.ResultsIn the pretherapeutic staging, WB-DWIBS/STIR showed very good agreement (kappa =0.96; confidence interval [CI], 0.88-1.00), high sensitivity (93.4-95.1%), and high specificity (99.0-99.4%) for the whole-body regions. These results were similar to those of F-18-FDG-PET/CT, except for the sensitivity for extranodal lesions. For extranodal lesions, WB-DWIBS/STIR showed higher sensitivity compared to F-18-FDG-PET/CT for the whole-body regions (94.9-96.8% vs. 79.6-86.3%, P=0.058).ConclusionWB-DWIBS/STIR is an effective modality for the pretherapeutic staging of indolent lymphoma, and it has benefits when evaluating extranodal lesions, compared with F-18-FDG-PET/CT.
Author(s)
류진숙서철원윤덕현이효상채선영채은진홍길선
Issued Date
2021
Type
Article
Keyword
AdultAgedBiopsyBone marrowClinical medicineConfidence intervalsDiagnostic imagingDiagnostic systemsDiffusion Magnetic Resonance Imaging - methodsDiffusion-weighted imaging with background body signalsuppressionEvaluationFemaleFluorine isotopesFluorodeoxyglucose F18HumansIndolent lymphomaLesionsLymphatic systemLymphomaLymphoma - diagnostic imagingLymphoma - pathologyMagnetic resonance imagingMaleMedical imagingMiddle AgedMultimodal Imaging - methodsPositron Emission Tomography Computed Tomography - methodsProspective StudiesRadiopharmaceuticalsResearchSensitivitySensitivity and SpecificitySoftwareSpleenStandard deviationStatistical analysisT2-weighted short-tau inversion recovery MRITomographyWhole Body Imaging - methodsWhole-body magnetic resonance imagingYoung Adult
DOI
10.1186/s40644-020-00371-6
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7326
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_18c1c38319fd438ca70d7f9c58a63f9c&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Assessment%20of%20naive%20indolent%20lymphoma%20using%20whole-body%20diffusion-weighted%20imaging%20and%20T2-weighted%20MRI:%20results%20of%20a%20prospective%20study%20in%2030%20patients&offset=0&pcAvailability=true
Publisher
CANCER IMAGING
Location
미국
Language
영어
ISSN
1740-5025
Citation Volume
21
Citation Number
1
Citation Start Page
5
Citation End Page
5
Appears in Collections:
Medicine > Medicine
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