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Malignancy risk of thyroid nodules with nonshadowing echogenic foci

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Abstract
Purpose: This study was conducted to determine the malignancy risk and diagnostic value of various types of nonshadowing echogenic foci (NEF) in the risk stratification of thyroid nodules.

Methods: A total of 1,018 consecutive thyroid nodules (>= 1 cm) with final diagnoses were included. The presence of NEF was determined and types of NEF were classified according to the presence of a comet tail artifact (CTA), location, and size through a prospective evaluation. The associations with malignancy, malignancy risk, and diagnostic value of various types of NEF were assessed.

Results: Intrasolid punctate NEF without CTA was the only type of NEF that was an independent predictor of malignancy (P<0.001). The malignancy risk of intrasolid punctate NEF without CTA was substantially higher in solid hypoechoic nodules than in isoechoic or nonsolid nodules (71.3% vs. 9.2%, P<0.001). In solid hypoechoic nodules, slightly increased sensitivity (70.8% vs. 67.9%) for malignancy and a similar malignancy risk (71.4% vs. 71.3%) were observed for intrasolid punctate NEF (with or without CTA) and intrasolid punctate NEF without CTA, respectively. NEF with CTA at the margin of the cystic component was not associated with malignancy or benignity in nonsolid nodules (P>0.05).

Conclusion: Intrasolid punctate NEF without CTA was the only independent predictor of malignancy. However, solid hypoechoic nodules with intrasolid punctate NEF should be classified as high-suspicion nodules regardless of coexisting CTA. Other types of NEF had no added value for detecting malignancy compared to intrasolid punctate NEF without CTA.
Author(s)
손유미나동규백우열권혜윤노병주
Issued Date
2021
Type
Article
Keyword
OriginalThyroidThyroid neoplasmsThyroid noduleUltrasonography방사선과학
DOI
10.14366/usg.20012
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7337
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9638108&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Malignancy%20risk%20of%20thyroid%20nodules%20with%20nonshadowing%20echogenic%20foci&amp;offset=0&amp;pcAvailability=true
Publisher
ULTRASONOGRAPHY
Location
대한민국
Language
영어
ISSN
2288-5919
Citation Volume
40
Citation Number
1
Citation Start Page
115
Citation End Page
125
Appears in Collections:
Medicine > Medicine
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