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Impact of liver-stiffness measurement on hepatocellular carcinoma development in chronic hepatitis C patients treated with direct-acting antivirals: A systematic review and time-to-event meta-analysis

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Abstract
Background and Aim: Patients with chronic hepatitis C (CHC) treated with direct-acting antivirals (DAAs) are still at risk for developing hepatocellular carcinoma (HCC) even after achieving sustained virologic response (SVR). Liver-stiffness measurement (LSM) on imaging has been investigated as a predictor of HCC occurrence. Objectives: To provide systematic summary of the predictive value of LSM in predicting HCC occurrence in HCV patients treated with DAA. Methods: A comprehensive literature search of the PubMed?MEDLINE and EMBASE databases was performed to identify studies that evaluated the predictive value of LSM in CHC patients treated with DAAs. Pooled hazard ratio (HR) comparing HCC occurrence between patients with positive and negative results on LSM was calculated for all studies and various subgroups. Subgroup analyses and meta-regression were performed. Results: A review of 135 candidate articles identified eight eligible articles with a total of 3398patients for qualitative review and meta-analysis. The pooled HR for HCC occurrence determined by LSM was 3.43 (95% confidence interval [CI], 1.63?7.19) with heterogeneity (I
Author(s)
유명원김경원심재준표준희
Issued Date
2021
Type
Article
Keyword
Chronic hepatitis CDirect-acting antiviralsHepatocellular carcinomaLiver-stiffness measurementSustained virologic response
DOI
10.1111/jgh.15243
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7364
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2439623774&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Impact%20of%20liver-stiffness%20measurement%20on%20hepatocellular%20carcinoma%20development%20in%20chronic%20hepatitis%20C%20patients%20treated%20with%20direct-acting%20antivirals:%20A%20systematic%20review%20and%20time-to-event%20meta-analysis&offset=0&pcAvailability=true
Publisher
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Location
오스트리아
Language
영어
ISSN
0815-9319
Citation Volume
36
Citation Number
3
Citation Start Page
601
Citation End Page
608
Appears in Collections:
Medicine > Medicine
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