Prognostic value of the 21-gene recurrence score for regional recurrence in patients with estrogen receptor-positive breast cancer
- Abstract
- Purpose To evaluate the prognostic value of the 21-gene recurrence score (RS) for regional recurrence (RR) in patients with estrogen receptor-positive breast cancer. Methods We reviewed the medical records of 446 patients who underwent 21-gene RS assay after breast-conserving surgery or mastectomy. The high-RS group was defined as patients who were (1) older than 50 years with an RS of 26 or higher, or (2) 50 years or younger with an RS of 16 or higher. Results The 5-year rates of local recurrence (LR), RR, and distant metastasis (DM) were 2.2%, 2.7%, and 4.7%, respectively. The 5-year overall survival (OS) rate was 99.1%. Of the patients, 269 (60.3%) had low-RS, while 177 (39.7%) had high-RS. The 5-year OS rate of the high-RS group was significantly lower than that of the low-RS. The 5-year rates of RR and DM in the high-RS group were significantly higher than those in the low-RS group, while the LR rates did not differ significantly. In multivariable analysis, the high-RS group had a significant relationship with increased RR rate (p = 0.037). Patients who had both high-RS and clinical high-risk features had a significantly higher 5-year RR rate (7.9%) compared with other groups. Conclusions High-RS was an independent risk factor for RR. The significantly higher RR rate of patients with both high-RS and clinical high-risk features compared with other groups suggests that this patient group can be a potential candidate for regional nodal irradiation.
- Author(s)
- 고민지; 정진홍; 김수산; 안승도; 최은경; 정일용; 이종원; 김성배; 정재호
- Issued Date
- 2021
- Type
- Article
- Keyword
- Breast cancer; 21-gene recurrence score; Oncotype DX; Regional recurrence
- DOI
- 10.1007/s10549-021-06228-1
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/7389
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2518219808&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20value%20of%20the%2021-gene%20recurrence%20score%20for%20regional%20recurrence%20in%20patients%20with%20estrogen%20receptor-positive%20breast%20cancer&offset=0&pcAvailability=true
- Publisher
- BREAST CANCER RESEARCH AND TREATMENT
- Location
- 미국
- Language
- 한국어
- ISSN
- 0167-6806
- Citation Volume
- 188
- Citation Number
- 3
- Citation Start Page
- 583
- Citation End Page
- 592
-
Appears in Collections:
- Medicine > Medicine
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.