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Prognostic value of the 21-gene recurrence score for regional recurrence in patients with estrogen receptor-positive breast cancer

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Abstract
Purpose To evaluate the prognostic value of the 21-gene recurrence score (RS) for regional recurrence (RR) in patients with estrogen receptor-positive breast cancer. Methods We reviewed the medical records of 446 patients who underwent 21-gene RS assay after breast-conserving surgery or mastectomy. The high-RS group was defined as patients who were (1) older than 50 years with an RS of 26 or higher, or (2) 50 years or younger with an RS of 16 or higher. Results The 5-year rates of local recurrence (LR), RR, and distant metastasis (DM) were 2.2%, 2.7%, and 4.7%, respectively. The 5-year overall survival (OS) rate was 99.1%. Of the patients, 269 (60.3%) had low-RS, while 177 (39.7%) had high-RS. The 5-year OS rate of the high-RS group was significantly lower than that of the low-RS. The 5-year rates of RR and DM in the high-RS group were significantly higher than those in the low-RS group, while the LR rates did not differ significantly. In multivariable analysis, the high-RS group had a significant relationship with increased RR rate (p = 0.037). Patients who had both high-RS and clinical high-risk features had a significantly higher 5-year RR rate (7.9%) compared with other groups. Conclusions High-RS was an independent risk factor for RR. The significantly higher RR rate of patients with both high-RS and clinical high-risk features compared with other groups suggests that this patient group can be a potential candidate for regional nodal irradiation.
Author(s)
고민지정진홍김수산안승도최은경정일용이종원김성배정재호
Issued Date
2021
Type
Article
Keyword
Breast cancer21-gene recurrence scoreOncotype DXRegional recurrence
DOI
10.1007/s10549-021-06228-1
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7389
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2518219808&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20value%20of%20the%2021-gene%20recurrence%20score%20for%20regional%20recurrence%20in%20patients%20with%20estrogen%20receptor-positive%20breast%20cancer&offset=0&pcAvailability=true
Publisher
BREAST CANCER RESEARCH AND TREATMENT
Location
미국
Language
한국어
ISSN
0167-6806
Citation Volume
188
Citation Number
3
Citation Start Page
583
Citation End Page
592
Appears in Collections:
Medicine > Medicine
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