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Performance of Prostate Imaging Reporting and Data System Version 2.1 for Diagnosis of Prostate Cancer: A Systematic Review and Meta-Analysis

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Abstract
Background The Prostate Imaging Reporting and Data System (PI-RADS) was introduced in 2012 and updated to version 2.1 (v2.1) in early 2019 to improve diagnostic performance and interreader reliability.

Purpose To evaluate the diagnostic performance of PI-RADS v2.1 in comparison with v2.

Methods A systematic review and meta-analysis of the literature was performed using MEDLINE, EMBASE, and Cochrane databases to identify studies evaluating the diagnostic performance of PI-RADS v2.1 for diagnosing clinically significant prostate cancer (csPCa).

Study Type Systematic review and meta-analysis.

Subject One thousand two hundred forty-eight patients with 1406 lesions from 10 eligible articles.

Field Strength/sequence Conventional MR sequences at 1.5 T and 3 T.

Assessment Two reviewers independently identified and reviewed the original articles reporting diagnostic performance of PI-RADS v2.1.

Statistical Tests Meta-analytic summary sensitivity and specificity were calculated using a bivariate random effects model. Meta-analytic sensitivity and specificity between PI-RADS v2 and v2.1 were compared.

Results The pooled sensitivity and specificity of PI-RADS v2.1 were 87% (95% confidence intervals, 82-91%) and 74% (63-82%), respectively. In five studies available for a head-to-head comparison between PI-RADS v2.1 and v2, there were no significant differences in either sensitivity (90% [86-94%] vs. 88% [83-93%], respectively) or specificity (76% [59-93%] vs. 61% [39-83%], respectively; P = 0.37). The sensitivity and specificity were 81% (73-87%) and 82% (68-91%), respectively, for a PI-RADS score cutoff of >= 4, and 94% (88-97%) and 56% (35-97%) for >= 3. Regarding the zonal location, the sensitivity and specificity for the transitional zone only were 90% (84-96%) and 76% (62-90%) respectively, whereas for the whole gland they were 85% (79-91%) and 71% (57-85%).

Data Conclusion PI-RADS v2.1 demonstrated good overall performance for the diagnosis of csPCa. PI-RADS v2.1 tended to show higher specificity than v2, but the difference lacked statistical significance.

Level of Evidence 3

Technical Efficacy Stage 3
Author(s)
박계진최상현김미현김정곤정인갑
Issued Date
2021
Type
Article
Keyword
CancerDiagnosisdiagnostic performancePI‐RADSprostateProstate cancerversion 2.1
DOI
10.1002/jmri.27546
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7393
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2489254287&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Performance%20of%20Prostate%20Imaging%20Reporting%20and%20Data%20System%20Version%202.1%20for%20Diagnosis%20of%20Prostate%20Cancer:%20A%20Systematic%20Review%20and%20Meta-Analysis&offset=0&pcAvailability=true
Publisher
JOURNAL OF MAGNETIC RESONANCE IMAGING
Location
미국
Language
영어
ISSN
1053-1807
Citation Volume
54
Citation Number
1
Citation Start Page
103
Citation End Page
112
Appears in Collections:
Medicine > Medicine
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