KLI

Safety and efficacy of 10-fraction hypofractionated radiation therapy for non-small cell lung cancer

Metadata Downloads
Abstract
Purpose: To investigate the safety and efficacy of hypofractionated radiation therapy (HFRT) in patients with non-small cell lung cancer who are unfit for surgery or stereotactic body radiation therapy (SBRT) at our institution.Materials and Methods: From May 2007 to December 2018, HFRT was used to treat 68 lesions in 64 patients who were unsuitable for SBRT because of central tumor location, large tumor size, or contiguity with the chest wall. The HFRT schedule included a dose of 50?70 Gy delivered in 10 fractions over 2 weeks. The primary outcome was freedom from local progression (FFLP), and the secondary endpoints included overall survival (OS), disease-free survival, and toxicities.Results: The median follow-up period was 25.5 months (range, 5.3 to 119.9 months). The FFLP rates were 79.8% and 67.8% at 1 and 2 years, respectively. The OS rates were 82.8% and 64.1% at 1 and 2 years, respectively. A larger planning target volume was associated with lower FFLP (p = 0.023). Dose escalation was not associated with FFLP (p = 0.964). Four patients (6.3%) experienced grade 3?5 pulmonary toxicities. Tumor location, central or peripheral, was not associated with either grade 3 or higher toxicity.Conclusion: HFRT with 50?70 Gy in 10 fractions demonstrated acceptable toxicity; however, the local control rate can be improved compared with the results of SBRT. More studies are required in patients who are unfit for SBRT to investigate the optimal fractionation scheme.
Author(s)
유예진김수산송시열김종훈안승도이상욱윤상민김영석박진홍정진홍최은경
Issued Date
2021
Type
Article
Keyword
Non-small cell lung carcinomasRadiation dose fractionationRadiation dose hypofractionationTreatment outcomeToxicity
DOI
10.3857/roj.2021.00416
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7405
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9871990&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Safety%20and%20efficacy%20of%2010-fraction%20hypofractionated%20radiation%20therapy%20for%20non-small%20cell%20lung%20cancer&offset=0&pcAvailability=true
Publisher
Radiation oncology journal
Location
대한민국
Language
한국어
ISSN
2234-1900
Citation Volume
39
Citation Number
3
Citation Start Page
202
Citation End Page
209
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.