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Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia

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Abstract
Myosteatosis, which is excessive fat infiltration in the skeletal muscle, is now considered a distinct disease from sarcopenia. Advances in imaging technique have made muscle parameters an evaluable biomarker, and many studies have proved association between myosteatosis and aging or disease process. However, the diagnosis and clinical impact of myosteatosis have not been well established. Thus, we aim to provide a systematic summary with a qualitive review of 73 eligible studies regarding these issues. First, the most widely used modality to diagnose myosteatosis is abdominal computed tomography, based on evaluation of the muscle radiodensity of the total abdominal muscle area predominantly at the L3 vertebral level. However, there was significant het-erogeneity in the diagnostic methods and cutoff values used to diagnose myosteatosis (32 different cutoff values among 73 studies). Second, the clinical impact of myosteatosis on prognosis was very straightforward, and most studies have shown a negative impact of myosteatosis on overall survival and complications related to underlying diseases. However, the mechanism of the myosteatosis on mortality has not been explored well, and metabolic dysfunction (i.e. insulin resistance, systemic inflammation) would be a possible explanation. Providing systemic review of current issues can elucidate future directions for developing standardized diagnosis and management of myosteatosis.
Author(s)
안혜민김동욱고유선하지연신영빈이지우성유섭김경원
Issued Date
2021
Type
Article
Keyword
Cross-sectional imagingCT imagingDiagnosisHealth aspectsInsulin resistanceMedical collegesMedical researchMedicineExperimentalMuscleMusclesMyosteatosisPrognosisSarcopeniaStandardization
DOI
10.1016/j.arr.2021.101398
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7408
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2548398817&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Updated%20systematic%20review%20and%20meta-analysis%20on%20diagnostic%20issues%20and%20the%20prognostic%20impact%20of%20myosteatosis:%20A%20new%20paradigm%20beyond%20sarcopenia&offset=0&pcAvailability=true
Publisher
AGEING RESEARCH REVIEWS
Location
영국
Language
영어
ISSN
1568-1637
Citation Volume
70
Citation Number
0
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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