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Reference Data and T-Scores of Lumbar Skeletal Muscle Area and Its Skeletal Muscle Indices Measured by CT Scan in a Healthy Korean Population

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Abstract
Background: Although computed tomography (CT) is considered the gold standard for investigating skeletal muscles, diagnostic cutoff points
for sarcopenia have not been established. We therefore suggested clinically relevant diagnostic cutoff points for sarcopenia based on reference
values of skeletal muscle area (SMA) measured by CT scan in a large-sized healthy Asian population.
Methods: This cross-sectional analysis included 11,845 subjects (7,314 men, 4,531 women) who underwent abdominal CT scans in South
Korea. SMA including all muscles on the selected axial images of the L3 lumbar vertebrae level was demarcated using predetermined thresholds
(?29 to +150 Hounsfield units). SMA indices (height-, weight-, and body mass index [BMI]-adjusted) were calculated.
Results: When T-score < ?2.0 was used as the cutoff for defining sarcopenia, the sex-specific cutoff points of SMA, SMA/height2
, SMA/weight,
and SMA/BMI were 119.3 and 74.2 cm2
, 39.8 and 28.4 cm2
/m2
, 1.65 and 1.38 cm2
/kg, and 4.97 and 3.46 in men and women, respectively. In
both sexes, the SMA/BMI values peaked in the 20s and decreased gradually. The SMA/BMI yielded the highest diagnostic rate of sarcopenia
(4.2% in men, 8.7% in women), while SMA/height2
provided the lowest yield (2.8% in men, 1.0% in women).
Conclusions: This is the first study to report the reference values of SMA and skeletal muscle indices (SMIs) measured on CT scans and to
suggest cutoff points for diagnosis of sarcopenia based on T-score in Asian subjects. BMI-adjusted index (SMA/BMI) was the best index of
CT-measured SMA to reflect the age-related muscle changes and to maximize the diagnostic yield for sarcopenia.
Author(s)
김경원김은희최재원신용빈이지우고유선김예지이민정배성진박성원김홍규
Issued Date
2021
Type
Article
Keyword
Skeletal muscle areaSkeletal muscle indicesL3 lumbar spine levelCT scanAsian
DOI
10.1093/gerona/glaa065
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7409
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1093_gerona_glaa065&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Reference%20Data%20and%20T-Scores%20of%20Lumbar%20Skeletal%20Muscle%20Area%20and%20Its%20Skeletal%20Muscle%20Indices%20Measured%20by%20CT%20Scan%20in%20a%20Healthy%20Korean%20Population&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Location
미국
Language
영어
ISSN
1079-5006
Citation Volume
76
Citation Number
2
Citation Start Page
265
Citation End Page
271
Appears in Collections:
Medicine > Medicine
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