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Magnetic Resonance Imaging for Surveillance of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

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Abstract
Our meta-analysis aimed to evaluate the diagnostic performance of surveillance magnetic resonance imaging (sMRI) for detecting hepatocellular carcinoma (HCC), and to compare the diagnostic performance of sMRI between different protocols. Original articles about the diagnostic accuracy of sMRI for detecting HCC were found in major databases. The meta-analytic pooled sensitivity and specificity of sMRI for detecting HCC were determined using a bivariate random effects model. The pooled sensitivity and specificity of full MRI and abbreviated MRI protocols were compared using bivariate meta-regression. In the total seven included studies (1830 patients), the pooled sensitivity of sMRI for any-stage HCC and very early-stage HCC were 85% (95% confidence interval, 79-90%; I-2 = 0%) and 77% (66-85%; I-2 = 32%), respectively. The pooled specificity for any-stage HCC and very early-stage HCC were 94% (90-97%; I-2 = 94%) and 94% (88-97%; I-2 = 96%), respectively. The pooled sensitivity and specificity of abbreviated MRI protocols were 87% (80-94%) and 94% (90-98%), values that were comparable with those of full MRI protocols (84% [76-91%] and 94% [89-99%]; p = 0.83). In conclusion, sMRI had good sensitivity for detecting HCC, particularly very early-stage HCC. Abbreviated MRI protocols for HCC surveillance had comparable diagnostic performance to full MRI protocols.
Author(s)
김동환최상현심주현김소연이승수변재호김경원최준일
Issued Date
2021
Type
Article
Keyword
liver hepatocellular carcinoma surveillance magnetic resonance imaging systematic review meta-analysis
DOI
10.3390/diagnostics11091665
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7424
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_77256a8d4a044d6892e124d946125ae6&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Magnetic%20Resonance%20Imaging%20for%20Surveillance%20of%20Hepatocellular%20Carcinoma:%20A%20Systematic%20Review%20and%20Meta-Analysis&offset=0&pcAvailability=true
Publisher
DIAGNOSTICS
Location
스위스
Language
한국어
ISSN
2075-4418
Citation Volume
11
Citation Number
9
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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