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Reduction of Visceral Adiposity as a Predictor for Resolution of Nonalcoholic Fatty Liver in Potential Living Liver Donors

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Abstract
This study aimed to determine the factors associated with resolution of nonalcoholic fatty liver (NAFL) after lifestyle intervention in potential living liver donors as assessed by the gold standards in a longitudinal setting. This retrospective study included 115 potential living liver donors (mean age, 30.5 +/- 7.5 years; 101 men) with NAFL who underwent paired liver biopsies and abdominal computed tomography (CT) examinations before and after lifestyle intervention between January 2011 and December 2018. Anthropometry, laboratory parameters, body composition, and hepatic steatosis (HS) were evaluated before and after lifestyle intervention. Anthropometry, laboratory parameters, body composition, and HS were significantly decreased after lifestyle intervention (all, P < 0.001). Relative changes in HS were weakly correlated with relative changes in the visceral fat area (VFA; r = 0.278; P = 0.003) and subcutaneous fat area (r = 0.382; P < 0.001), but not with body weight, body mass index, or skeletal muscle area. Patients with resolved NAFL after lifestyle intervention had significantly lower VFA at follow-up than those with persistent NAFL (mean +/- standard deviation, 69.8 +/- 39.1 versus 91.5 +/- 41.4 cm(2); P = 0.01). Multivariable logistic regression analysis demonstrated that the relative reduction of VFA (odds ratio per percent, 1.031; 95% confidence interval, 1.010-1.053; P = 0.004) was a significant independent factor associated with resolved NAFL after lifestyle intervention. In potential living liver donors with NAFL, the reduction of VFA is a significant factor associated with the resolution of NAFL after lifestyle intervention.
Author(s)
이선영김경원이정진박태용박효정송기원이승규
Issued Date
2021
Type
Article
Keyword
Adipose tissueAnthropometryBiopsyBody compositionBody mass indexBody weightComputed tomographyFatty liverLaboratoriesLifestylesLiverSkeletal muscleSteatosis
DOI
10.1002/lt.26071
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7443
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2511238425&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Reduction%20of%20Visceral%20Adiposity%20as%20a%20Predictor%20for%20Resolution%20of%20Nonalcoholic%20Fatty%20Liver%20in%20Potential%20Living%20Liver%20Donors&amp;offset=0&amp;pcAvailability=true
Publisher
LIVER TRANSPLANTATION
Location
미국
Language
영어
ISSN
1527-6465
Citation Volume
27
Citation Number
10
Citation Start Page
1424
Citation End Page
1431
Appears in Collections:
Medicine > Medicine
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