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Visceral adiposity as a risk factor for lean non-alcoholic fatty liver disease in potential living liver donors

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Abstract
Background and Aim This study aimed to investigate the relationship between hepatic steatosis (HS) evaluated by biopsy and visceral adiposity assessed by computed tomography in lean living liver donor candidates and to determine the risk factors for lean non-alcoholic fatty liver disease (NAFLD). Methods This retrospective study included 250 lean (body mass index, < 23 kg/m(2)) potential living liver donors (mean age, 31.1 +/- 8.6 years; 141 men) who had undergone liver biopsy and abdominal computed tomography between 2017 and 2018. Anthropometry, laboratory parameters, body composition, and the degree of HS were evaluated. Logistic regression was used to identify independent predictors of lean NAFLD. Results The visceral fat area (VFA) was significantly correlated with the degree of HS in men (r = 0.408; P < 0.001) and women (r = 0.360; P < 0.001). The subcutaneous fat area was significantly correlated with the degree of HS in men (r = 0.398; P < 0.001), but not in women. The skeletal muscle area did not correlate with the degree of HS in either men or women. In the multivariable logistic regression analysis, the VFA (odds ratio [OR], 1.028; 95% confidence interval [CI], 1.013-1.044; P < 0.001) and subcutaneous fat area (OR, 1.016; 95% CI, 1.004-1.028; P = 0.009) were independent risk factors for lean NAFLD in men, and the VFA (OR, 1.036; 95% CI, 1.013-1.059; P = 0.002) was an independent risk factor for lean NAFLD in women. Conclusions The severity of non-alcoholic fatty liver was positively correlated with visceral fat accumulation in a lean Asian population. Visceral adiposity may be a risk factor for lean NAFLD in potential living liver donors.
Author(s)
이선영김경원이정진박태용강승우정희열송기원이승규
Issued Date
2021
Type
Article
Keyword
Adipose tissueAdipose tissuesBody mass indexCT imagingFatty liverMedical researchMedicineExperimentalMusclesNon-alcoholic fatty liver diseaseRisk factorRisk factorsTransplantation of arganstissuesetc
DOI
10.1111/jgh.15597
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7444
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2545594186&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Visceral%20adiposity%20as%20a%20risk%20factor%20for%20lean%20non-alcoholic%20fatty%20liver%20disease%20in%20potential%20living%20liver%20donors&amp;offset=0&amp;pcAvailability=true
Publisher
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Location
미국
Language
영어
ISSN
0815-9319
Citation Volume
36
Citation Number
11
Citation Start Page
3212
Citation End Page
3218
Appears in Collections:
Medicine > Medicine
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