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Feasibility of a Drug-Releasing Radiofrequency Ablation System in a Porcine Liver Model

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Abstract
The objective of this study was to investigate the feasibility of a newly developed anticancer drug-releasing radiofrequency ablation (RFA) system in a porcine liver model. A 15-gauge drug-releasing cooled wet electrode (DRCWE) was newly developed to improve the RFA efficacy for creating a large ablation as well as for simultaneously delivering an anticancer drug to the tumor margin. Nine ablations in three pigs were performed by the DRCWE. The sectioned liver specimens were evaluated by measuring the ablation zone by a positron emission tomography/magnetic resonance imaging examination to investigate whether F-18-fluorodeoxyglucose was exactly diffused. Volumes of the ablation zones released drug injection volumes, circularity, retention rate defined as the ratio between an estimated and injection dose, and the standard uptake value were assessed. The drug-releasing RFA was technically successful without procedural-related complications. During the procedure, the color changes of the ablated zones of the liver were observed in all specimens. The mean drug injection volume was higher than the ablated volumes (17.21 +/- 2.85 vs. 15.22 +/- 2.30 cm(3)) and the circularity was 0.72 +/- 0.08. Moreover, the retention rate was 72.89% +/- 4.22% and the mean standard uptake value was 0.44 +/- 0.05. The drug-releasing RFA system was feasible not only for local ablation but also for the delivery of anticancer drugs. The results of this study indicate that this novel strategy of localized RFA with a drug delivery system could be a promising option for the prevention of local recurrence rates.
Author(s)
조영철이기백함수정정진화박유빈원동성김경원박정훈
Issued Date
2021
Type
Article
Keyword
drug-releasing radiofrequency ablationanticancer drug-releasing cooled wet electrodelocal recurrence rate
DOI
10.3390/app11188301
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7447
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_341586f3e1964c0ab562534d95e94ed5&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Feasibility%20of%20a%20Drug-Releasing%20Radiofrequency%20Ablation%20System%20in%20a%20Porcine%20Liver%20Model&offset=0&pcAvailability=true
Publisher
APPLIED SCIENCES-BASEL
Location
스위스
Language
영어
ISSN
2076-3417
Citation Volume
11
Citation Number
18
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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