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Comparative Analysis of Hyaluronidase-Mediated Degradation Among Seven Hyaluronic Acid Fillers in Hairless Mice

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Abstract
Purpose: Hyaluronic acid (HA) is the most common injectable dermal filler used for soft-tissue augmentation, and can be removed non-surgically by directly injecting hyaluronidase. In this study, the hyaluronidase-mediated degradation of different types of HA fillers implanted subcutaneously at the back of hairless mice having filler residence time of four days or three months were compared.

Methods: Two sites at the back of female hairless mice were subcutaneously implanted with 0.1-mL of one of the seven HA fillers (NLL, NL, NDL, NVL, and ND, JUV(X+), and RESLYFT) and injected with 30 IU or 60 IU hyaluronidase per 0.1-mL filler after reaching a filler residence time of 4 or 91 days, respectively. Filler bolus projection was measured using three-dimensional optical imaging over a 72 h period, and the implantation sites were histologically examined 2 weeks after hyaluronidase injection.

Results: Following hyaluronidase injection, all seven HA fillers showed a rapid decrease of filler volume within 24 h, and complete degradation was confirmed by histological examination after 2 weeks. There was no significant difference in filler volume reduction rate among the seven HA fillers, and no evidence of macroscopic or microscopic adverse effects were observed at the implantation sites.

Conclusion: All seven HA fillers show comparable susceptibility to hyaluronidase-mediated degradation. HA fillers with prolonged filler residence time may require a higher dose of hyaluronidase to achieve efficient degradation owing to tissue integration.
Author(s)
곽성성윤광호권진희강원호이창훈양기혁Deu John M Cruz손우찬
Issued Date
2021
Type
Article
Keyword
3D optical imagingComparative analysisDermal fillersfiller residence timeHA filler volumeHistologyHyaluronic acidLaboratory animalsOriginal ResearchPolymerssoft tissue augmentationtissue integrationTransplants & implants
DOI
10.2147/CCID.S300960
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7455
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_1e61e37060a74bd4ab597ba6a52620eb&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Comparative%20Analysis%20of%20Hyaluronidase-Mediated%20Degradation%20Among%20Seven%20Hyaluronic%20Acid%20Fillers%20in%20Hairless%20Mice&sortby=rank
Publisher
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
Location
영국
Language
영어
ISSN
1178-7015
Citation Volume
14
Citation Number
14
Citation Start Page
241
Citation End Page
248
Appears in Collections:
Medicine > Medicine
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