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Comparative Analyses of Inflammatory Response and Tissue Integration of 14 Hyaluronic Acid-Based Fillers in Mini Pigs

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Abstract
Purpose: Hyaluronic acid (HA)-based dermal fillers have been approved for various clinical indications, both cosmetic and medical. Previous studies that have assessed the performance of HA dermal fillers have primarily focused on evaluating filler durability, and only a few have studied their distribution within the tissues. The present study aimed to compare tissue integration of various types of HA dermal fillers having different clinical indications and varying injection depths.

Methods: To examine the local inflammatory response and distribution pattern of 14 HA dermal fillers (six Neuramis [NEU], one Belotero [BEL], three Juv eacute;derm [JUV], and four Restylane [RES]), each product was injected intradermally and subcutaneously at the backs of two male miniature pigs. Histopathological evaluation and visual examination of the tissue sections were conducted 1 and 4 weeks after injection.

Results: Mean inflammatory cell infiltration scores tended to be lower in response to fillers from the NEU and BEL series than to those from the JUV and RES series after intradermal and subcutaneous injection. Furthermore, the inflammatory response to fillers with higher physicochemical properties specifically designed for injection into deeper layers of the skin tended to be slightly higher than those designated for injection into more superficial layers. There was no significant difference in tissue integration according to clinical indication and injection depth, although fillers from the NEU and BEL series exhibited better tissue integration than those from the JUV and RES series .

Conclusion: Our findings not only suggest that the local inflammatory response and tissue integration differ across HA dermal filler products, but also that these parameters could vary according to the recommended clinical indication and injection depth of the products.
Author(s)
최민서곽성성김준형박미선고수민김태희정다솜이창훈양기혁손우찬강원호
Issued Date
2021
Type
Article
Keyword
histopathologyinflammatory responseHA fillersoft tissueargumentation tissueintegration
DOI
10.2147/CCID.S315076
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7457
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_7f551743c39f43e183950eeeb6875d11&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Comparative%20Analyses%20of%20Inflammatory%20Response%20and%20Tissue%20Integration%20of%2014%20Hyaluronic%20Acid-Based%20Fillers%20in%20Mini%20Pigs&offset=0&pcAvailability=true
Publisher
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
Location
미국
Language
한국어
ISSN
1178-7015
Citation Volume
14
Citation Start Page
765
Citation End Page
778
Appears in Collections:
Medicine > Medicine
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