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Differential contribution of the factors determining long-term renal function after partial nephrectomy over time

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Abstract
Purpose: To define how much of renal function was determined by the preserved renal parenchymal volume and the ischemic insult during partial nephrectomy (PN) long after surgery.

Methods: We analyzed the data of 530 consecutive patients who had undergone PN. For all patients, renal function was measured preoperatively and again at 3 postoperative months, then annually using Tc-99m-diethylenetriaminepentaacetic acid renal scan. Perioperative variables potentially affecting the long-term ipsilateral glomerular filtration rate (GFR) and their time-varying contribution were assessed using a linear mixed model.

Results: The mean preoperative ipsilateral GFR was 42.9 ml/min, which decreased by 27.3% at 3 months but began to recover thereafter continuing until 4 years (Delta% GFR at 1, 2, 3, 4, and 5 years: 22.3%, 18.5%, 14.7%, 10.0%, and 9.6%, respectively). Parenchymal volume reduction and ischemic time were significantly associated with postoperative ipsilateral GFR throughout observation period unvarying with time. Diabetes and proteinuria were not significant determinants of ipsilateral function at 3 months but became significant at 5 years. In multivariate analysis regarding recovery slope, volume reduction (beta = -0.026, SE 0.006, P < 0.0001), preoperative ipsilateral GFR (beta = -0.021, SE 0.007, P = 0.0012), proteinuria (beta = -0.942, SE 0.372, P = 0.0116), and diabetes (beta = -0.396, SE 0.197, P = 0.0447) were independently significant.

Conclusion: Ipsilateral renal function continued to improve until 5 years after PN. Parenchymal volume loss was the major determinant and its impact on long-term ipsilateral renal function remained constant while ischemic time affected early GFR reduction with its impact diminishing over time. Patient-related factors including diabetes and proteinuria gained significance over time and became independent determinants of recovery slope. (C) 2020 Elsevier Inc. All rights reserved.
Author(s)
이종필송채린이동현김종근유달산정인갑홍범식홍준혁김청수안한종
Issued Date
2021
Type
Article
Keyword
Partial nephrectomyRenal functionGFRDTPA scanRenal volume
DOI
10.1016/j.urolonc.2020.11.007
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7471
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2470025442&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Differential%20contribution%20of%20the%20factors%20determining%20long-term%20renal%20function%20after%20partial%20nephrectomy%20over%20time&amp;offset=0&amp;pcAvailability=true
Publisher
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
Location
미국
Language
영어
ISSN
1078-1439
Citation Volume
39
Citation Number
3
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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