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Impact of metformin on survival outcome in ovarian cancer: a nationwide population-based cohort study

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Abstract
Objective: Investigation of new drugs (INDs) is a tremendously inefficient process in terms of time and cost. Drug repositioning is another method used to investigate potential new agents in well-known drugs. This study assessed the survival impact of metformin medication on ovarian cancer.

Methods: A national sample cohort of the Korean National Health Insurance Service Data was analyzed. Cox proportional hazards regression was used to analyzing hazard ratios (HRs) and 95% confidence intervals (CIs) after adjusting for underlying diseases and medications as confounding factors for overall survival (OS) and cancer-specific survival (CSS).

Results: A total of 866 eligible patients were included from among 1,025,340 cohort participants. Among them, 101 (11.7%) were metformin users. No difference in OS was observed between non-users and users. No difference in OS was observed according to age and Charlson Comorbidity Index. Long-term metformin use (≥720 days) was associated with better OS (adjusted HR=0.244; 95% CI=0.090-0.664; p=0.006). A multivariate Cox proportional hazards model showed that long-term metformin use was an independent favorable prognostic factor for OS (HR=0.193; 95% CI=0.070-0.528; p=0.001) but not for CSS (HR=0.599; 95% CI=0.178-2.017; p=0.408).

Conclusion: Long-term metformin use reduced all-cause mortality, but not CSS in ovarian cancer. Whether metformin itself reduces deaths because of ovarian cancer requires further investigation.

Keywords: Metformin; Ovarian Neoplasms; Survival; Treatment Outcome.
Author(s)
김선옥박영한박정열백미현임명철
Issued Date
2021
Type
Article
Keyword
MetforminOvarian Neopla는SurvivalTreatment Outcome
DOI
10.3802/jgo.2021.32.e65
URI
http://oak.ulsan.ac.kr/handle/2021.oak/7508
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3888525&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Impact%20of%20metformin%20on%20survival%20outcome%20in%20ovarian%20cancer:%20a%20nationwide%20population-based%20cohort%20study&offset=0&pcAvailability=true
Publisher
Journal of Gynecologic Oncology
Location
대한민국
Language
영어
ISSN
2005-0380
Citation Volume
32
Citation Number
4
Citation Start Page
e65
Citation End Page
e65
Appears in Collections:
Medicine > Medicine
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