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In Vivo Evaluation of Dendropanax morbifera Leaf Extract for Anti-Obesity and Cholesterol-Lowering Activity in Mice

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Abstract
Metabolic syndrome is a worldwide health problem, and obesity is closely related to type 2 diabetes, cardiovascular disease, hypertension, and cancer. According to WHO in 2018, the prevalence of obesity in 2016 tripled compared to 1975. D. morbifera reduces bad cholesterol and triglycerides levels in the blood and provides various antioxidant nutrients and germicidal sub-stances, as well as selenium, which helps to remove active oxygen. Moreover, D. morbifera is useful for treating cardiovascular diseases, hypertension, hyperlipidemia, and diabetes. Therefore, we study in vivo efficacy of D. morbifera to investigate the prevention effect of obesity and cholesterol. The weight and body fat were effectively reduced by D. morbifera water (DLW) extract administration to high-fat diet-fed C57BL/6 mice compared to those of control mice. The group treated with DLW 500 mg center dot kg(-1)center dot d(-1) had significantly lower body weights compared to the control group. In addition, High-density lipoprotein (HDL) cholesterol increased in the group treated with DLW 500 mg center dot kg(-1)center dot d(-1). The effect of DLW on the serum lipid profile could be helpful to prevent obesity. DLW suppresses lipid formation in adipocytes and decreases body fat. In conclusion, DLW can be applied to develop anti-obesity functional foods and other products to reduce body fat.
Author(s)
송지혜김현희정민석공민정최효경전우진김용재최경철
Issued Date
2021
Type
Article
Keyword
cholesterolDendropanax morbiferain vivomethylisobutylxanthineobesity
DOI
10.3390/nu13051424
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7532
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_de8110c2e8c54fd0b76c96329e42824a&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,In%20Vivo%20Evaluation%20of%20Dendropanax%20morbifera%20Leaf%20Extract%20for%20Anti-Obesity%20and%20Cholesterol-Lowering%20Activity%20in%20Mice&offset=0&pcAvailability=true
Publisher
NUTRIENTS
Location
스위스
Language
한국어
ISSN
2072-6643
Citation Volume
13
Citation Number
5
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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