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Ubiquitin-Conjugating Enzymes in Cancer

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Abstract
The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The conjugation of ubiquitin to a target protein is mediated sequentially by the E1 (activating)-E2 (conjugating)-E3 (ligating) enzyme cascade. Thus, E2 enzymes act as the central players in the ubiquitination system, modulating various pathophysiological processes in the tumor microenvironment. In this review, we summarize the types and functions of E2s in various types of cancer and discuss the possibility of E2s as targets of anticancer therapeutic strategies.
Author(s)
Quyen Thu BuiJeong Hee HongMinseok KwakJi Yeon Lee이창환
Issued Date
2021
Type
Article
Keyword
UbiquitinUbiquitin conjugating enzymecancer
DOI
10.3390/cells10061383
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7534
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_a43740e8bffa43df89c6fed6c6694c6b&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Ubiquitin-Conjugating%20Enzymes%20in%20Cancer&offset=0&pcAvailability=true
Publisher
CELLS
Location
스위스
Language
영어
ISSN
2073-4409
Citation Volume
10
Citation Number
10
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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