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Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

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Abstract
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.
Author(s)
Wei ZhangJuyoung HwangDhananjay YadavEun-Koung AnMinseok Kwak이창환Jun-O Jin
Issued Date
2021
Type
Article
Keyword
Lung CancerImmunotherapyanti-PD-L1Fucoidan
DOI
10.3390/ijms22179125
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7536
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_4f28e9e6f9c44dc5b2fa029f9385c267&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Enhancement%20of%20Immune%20Checkpoint%20Inhibitor-Mediated%20Anti-Cancer%20Immunity%20by%20Intranasal%20Treatment%20of%20Ecklonia%20cava%20Fucoidan%20against%20Metastatic%20Lung%20Cancer&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Location
스위스
Language
영어
ISSN
1422-0067
Citation Volume
22
Citation Number
17
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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