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The sulfiredoxin-peroxiredoxin redox system regulates the stemness and survival of colon cancer stem cells

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Abstract
Cancer stem cells (CSCs) initiate tumor formation and are known to be resistant to chemotherapy. A metabolic alteration in CSCs plays a critical role in stemness and survival. However, the association between mitochondrial energy metabolism and the redox system remains undefined in colon CSCs. In this study, we assessed the role of the Sulfiredoxin-Peroxiredoxin (Srx-Prx) redox system and mitochondrial oxidative phosphorylation (OXPHOS) in maintaining the stemness and survival of colon CSCs. Notably, Srx contributed to the stability of PrxI, PrxII, and PrxIII proteins in colon CSCs. Increased Srx expression promoted the stemness and survival of CSCs and was important for the maintenance of the mitochondrial OXPHOS system. Furthermore, Nrf2 and FoxM1 led to OXPHOS activation and upregulated expression of Srx-Prx redox system-related genes. Therefore, the Nrf2/FoxM1-induced Srx-Prx redox system is a potential therapeutic target for eliminating CSCs in colon cancer.
Author(s)
송인성정유정정유나박영호심성보김성주엄대운홍승모이창환김선욱장성욱
Issued Date
2021
Type
Article
Keyword
coloncancer stem cellsulfiredoxinperoxiredoxinstemnessrosoxphos
DOI
10.1016/j.redox.2021.102190
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7540
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_170ecf4e8064481e84374c2fee219475&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20sulfiredoxin-peroxiredoxin%20redox%20system%20regulates%20the%20stemness%20and%20survival%20of%20colon%20cancer%20stem%20cells&offset=0&pcAvailability=true
Publisher
Redox Biology
Location
네덜란드
Language
영어
ISSN
2213-2317
Citation Volume
48
Citation Start Page
102190
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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