KLI

Localized Photothermal Ablation Therapy of Obstructive Rectal Cancer Using a Nanofunctionalized Stent in a Mouse Model

Metadata Downloads
Abstract
The self-expanding metal stent (SEMS) is a versatile, palliative treatment method for unresectable, malignant, non-vascular strictures. Colorectal cancer (CRC) is one of the candidates for the application of the SEMS, in combination with the photothermal ablation (PTA) technique that enhances its therapeutic efficacy. The objective of this study was to investigate the efficacy of stent-mediated PTA therapy in an endoscopy-guided, orthotopic rectal cancer model. A total of 30 of 40 mice with the tumor size of grade 4 were included and were divided into three groups of 10 mice each. Group A underwent a gold nanoparticle (AuNP)-coated SEMS but no near-infrared (NIR) irradiation, group B received an uncoated control SEMS with NIR irradiation, and group C received a AuNP-coated SEMS and NIR irradiation together. Colonoscopy and in vivo imaging, immunohistochemical analysis, and quantitative reverse-transcription polymerase chain reaction of major tumor markers were performed. Stent placement and PTA were technically successful using colonoscopy. The tumor grade reduction after PTA is significant in group C, compared with groups A or B (p < 0.001). Molecular analysis validated this observation with a significantly reduced Mapk1 proliferation marker or increased Jnk expression. Histological analysis confirmed the localized PTA therapy using AuNP-coated SEMS profoundly ablated tumor outgrowth through the stent. Our results indicate that this novel strategy of localized PTA therapy could be a promising option for palliative treatment of CRC and to support prolonged stent patency with a decreased tumor volume.
Author(s)
김동현김송희송호영이은지Hong Tao HuNader BakheetShi-Jun XuZhe Wang박정훈전재용장수환
Issued Date
2021
Type
Article
Keyword
colorectal cancerself-expandable metallic stentgold nanoparticleorthotopic colon cancer modelphotothermal ablation
DOI
10.1021/acsbiomaterials.1c01166
URI
https://oak.ulsan.ac.kr/handle/2021.oak/7541
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2601978817&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Localized%20Photothermal%20Ablation%20Therapy%20of%20Obstructive%20Rectal%20Cancer%20Using%20a%20Nanofunctionalized%20Stent%20in%20a%20Mouse%20Model&amp;offset=0&amp;pcAvailability=true
Publisher
ACS Biomaterials Science & Engineering
Location
미국
Language
영어
ISSN
2373-9878
Citation Volume
7
Citation Number
12
Citation Start Page
5890
Citation End Page
5898
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.